Fabrication and characterization of electrospun chitosan/polylactic acid (CH/PLA) nanofiber scaffolds for biomedical application
Authors:
- Yevhen Samokhin,
- Yuliia Varava,
- Kateryna Diedkova,
- Ilya Yanko,
- Yevheniia Husak,
- Julia Radwan-Pragłowska,
- Oksana Pogorielova,
- Łukasz Janus,
- Maksym Pogorielov,
- Viktoriia Korniienko
Abstract
The present study demonstrates a strategy for preparing porous composite fibrous materials with superior biocompatibility and antibacterial performance. The findings reveal that the incorporation of PEG into the spinning solutions significantly influences the fiber diameters, morphology, and porous area fraction. The addition of a hydrophilic homopolymer, PEG, into the Ch/PLA spinning solution enhances the hydrophilicity of the resulting materials. The hybrid fibrous materials, comprising Ch modified with PLA and PEG as a co-solvent, along with post-treatment to improve water stability, exhibit a slower rate of degradation (stable, moderate weight loss over 16 weeks) and reduced hydrophobicity (lower contact angle, reaching 21.95 ± 2.17°), rendering them promising for biomedical applications. The antibacterial activity of the membranes is evaluated against Staphylococcus aureus and Escherichia coli, with PEG-containing samples showing a twofold increase in bacterial reduction rate. In vitro cell culture studies demonstrated that PEG-containing materials promote uniform cell attachment, comparable to PEG-free nanofibers. The comprehensive evaluation of these novel materials, which exhibit improved physical, chemical, and biological properties, highlights their potential for biomedical applications in tissue engineering and regenerative medicine.
- Record ID
- CUTbad29c1e851648eaba35da1a0ee3f520
- Publication categories
- ;
- Author
- Journal series
- Journal of Functional Biomaterials, ISSN , e-ISSN 2079-4983, Monthly
- Issue year
- 2023
- Vol
- 14
- No
- 8
- Pages
- [1-17]
- Article number
- 414
- Other elements of collation
- fot.; schem.; wykr.; Bibliografia (na s.) - 14-17; Bibliografia (liczba pozycji) - 56; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 14, Iss. 8
- Substantive notes
- Special Issue: Chitosan Microparticles: Development, Characterization and Biomedical Applications
- Keywords in English
- chitosan, polylactic acid, electrospinning, nanofibers, biocompatibility, antibacterial biomaterials
- DOI
- DOI:10.3390/jfb14080414 Opening in a new tab
- URL
- https://www.mdpi.com/2079-4983/14/8/414 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 100
- Score source
- journalList
- Score
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTbad29c1e851648eaba35da1a0ee3f520/
- URN
urn:pkr-prod:CUTbad29c1e851648eaba35da1a0ee3f520
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.