Therapeutic nail polishes based on ciclopirox
Authors:
- Anna K. Drabczyk,
- Patrycja Podobińska,
- Agnieszka Mamica,
- Jolanta Jaśkowska
Abstract
The aim of the research work was to create a nail polish formulation that would carry the therapeutic substance ciclopirox (ciclopiroxolamine), a drug with an exceptionally broad spectrum of activity, exhibiting antifungal, antibacterial, bacteriostatic and anti-inflammatory activity. The experiments conducted proved that ciclopirox can not only be released from the developed formulations when applied directly to the plate, but can also be applied to nails covered with cosmetic varnish. The amount of released active ingredient reaches the minimum inhibitory concentration for cyclopirox in Candida spp. infection. Which suggests that the formulations would be effective for fungal infections. The best results in terms of film formation were obtained for formulations that were based on PVP. The highest released drug concentration occurred with formulation No. 3 and was 4.47 (mg/10ml) after 24 hours.
- Record ID
- CUT5b22d03712134f19906b5d4d4b866616
- Publication categories
- ;
- Author
- Journal series
- Scientiae Radices, ISSN 2956-4808
- Issue year
- 2023
- Vol
- 2
- No
- 4
- Pages
- 347-358
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 357-358; Bibliografia (liczba pozycji) - 22; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 2, Iss. 4
- Keywords in English
- therapeutic nail polishes, ciclopirox, candida spp., onychomycosis
- DOI
- DOI:10.58332/scirad2023v2i4a04 Opening in a new tab
- URL
- https://sci-rad.com/scirad2023v2i4a04/ Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 20
- Score source
- journalList
- Score
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT5b22d03712134f19906b5d4d4b866616/
- URN
urn:pkr-prod:CUT5b22d03712134f19906b5d4d4b866616
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.