Naturally inspired molecules for neuropathic pain inhibition – effect of mirogabalin and cebranopadol on mechanical and thermal nociceptive threshold in mice
Authors:
- Kinga Sałat,
- Paula Zaręba,
- Michał Awtoniuk,
- Robert Sałat
Abstract
Background: Neuropathic pain is drug-resistant to available analgesics and therefore novel treatment options for this debilitating clinical condition are urgently needed. Recently, two drug candidates, namely mirogabalin and cebranopadol have become a subject of interest because of their potential utility as analgesics for chronic pain treatment. However, they have not been investigated thoroughly in some types of neuropathic pain, both in humans and experimental animals. Methods: This study used the von Frey test, the hot plate test and the two-plate thermal place preference test supported by image analysis and machine learning to assess the effect of intraperitoneal mirogabalin and subcutaneous cebranopadol on mechanical and thermal nociceptive threshold in mouse models of neuropathic pain induced by streptozotocin, paclitaxel and oxaliplatin. Results: Mirogabalin and cebranopadol effectively attenuated tactile allodynia in models of neuropathic pain induced by streptozotocin and paclitaxel. Cebranopadol was more effective than mirogabalin in this respect. Both drugs also elevated the heat nociceptive threshold in mice. In the oxaliplatin model, cebranopadol and mirogabalin reduced cold-exacerbated pain. Conclusions: Since mirogabalin and cebranopadol are effective in animal models of neuropathic pain, they seem to be promising novel therapies for various types of neuropathic pain in patients, in particular those who are resistant to available analgesics.
- Record ID
- CUT86ca37d32ee94b4986f049e59ad6876d
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2023
- Vol
- 28
- No
- 23
- Pages
- [1-19]
- Article number
- 7862
- Other elements of collation
- rys.; wykr.; Bibliografia (na s.) - 16-19; Bibliografia (liczba pozycji) - 84; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 28, Iss. 23
- Substantive notes
- Special Issue: Naturally Inspired Molecules as Inhibitors in Drug Discovery
- Keywords in English
- mirogabalin, cebranopadol, mouse models of neuropathic pain, machine learning, image analysis
- ASJC Classification
- DOI
- DOI:10.3390/molecules28237862 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/28/23/7862 Opening in a new tab
- Related project
- Opracowanie metody optymalizacji dawkowania leków przeciwbólowych stosowanych jako terapia skojarzona bólu neuropatycznego z wykorzystaniem metod sztucznej inteligencji. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT86ca37d32ee94b4986f049e59ad6876d/
- URN
urn:pkr-prod:CUT86ca37d32ee94b4986f049e59ad6876d
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.