Towards polycaprolactone-based scaffolds for alveolar bone tissue engineering: a biomimetic approach in a 3D printing technique
Authors:
- Krzysztof Stafin,
- Paweł Śliwa,
- Marek Piątkowski
Abstract
The alveolar bone is a unique type of bone, and the goal of bone tissue engineering (BTE) is to develop methods to facilitate its regeneration. Currently, an emerging trend involves the fabrication of polycaprolactone (PCL)-based scaffolds using a three-dimensional (3D) printing technique to enhance an osteoconductive architecture. These scaffolds are further modified with hydroxyapatite (HA), type I collagen (CGI), or chitosan (CS) to impart high osteoinductive potential. In conjunction with cell therapy, these scaffolds may serve as an appealing alternative to bone autografts. This review discusses research gaps in the designing of 3D-printed PCL-based scaffolds from a biomimetic perspective. The article begins with a systematic analysis of biological mineralisation (biomineralisation) and ossification to optimise the scaffold’s structural, mechanical, degradation, and surface properties. This scaffold-designing strategy lays the groundwork for developing a research pathway that spans fundamental principles such as molecular dynamics (MD) simulations and fabrication techniques. Ultimately, this paves the way for systematic in vitro and in vivo studies, leading to potential clinical applications.
- Record ID
- CUT0348a805a1bb41b2abae87ef05822a76
- Publication categories
- ;
- Author
- Journal series
- International Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067, Biweekly
- Issue year
- 2023
- Vol
- 24
- No
- 22
- Pages
- [1-43]
- Article number
- 16180
- Other elements of collation
- rys.; schem.; tab.; Bibliografia (na s.) - 31-43; Bibliografia (liczba pozycji) - 328; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 24, Iss. 22
- Substantive notes
- Special Issue: Latest Review Papers in Macromolecules 2023
- Keywords in English
- bone tissue engineering, alveolar bone, biomineralisation, biomimetic ossification, fused filament fabrication, 3D-printed PCL-based scaffold, hydroxyapatite, collagen, chitosan
- ASJC Classification
- ; ; ; ; ; ; ;
- DOI
- DOI:10.3390/ijms242216180 Opening in a new tab
- URL
- https://www.mdpi.com/1422-0067/24/22/16180 Opening in a new tab
- Related project
- Osteochit3D - personalizowane bioaktywne skafoldy drukowane 3D do zaawansowanej regeneracji tkanki kostnej w stomatologii. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT0348a805a1bb41b2abae87ef05822a76/
- URN
urn:pkr-prod:CUT0348a805a1bb41b2abae87ef05822a76
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.