Topical formulations based on ursolic acid-loaded nanoemulgel with potential application in psoriasis treatment
Authors:
- Małgorzata Miastkowska,
- Agnieszka Kulawik-Pióro,
- Elwira Lasoń,
- Karolina Śliwa,
- Magdalena Anna Malinowska,
- Elżbieta Sikora,
- Tomasz Kantyka,
- Ewa Bielecka,
- Anna Maksylewicz,
- Emilia Klimaszewska,
- Marta Ogorzałek,
- Małgorzata Tabaszewska,
- Łukasz Skoczylas,
- Krzysztof Nowak
Abstract
Psoriasis is a chronic disorder that causes a rash with itchy, scaly patches. It affects nearly 2–5% of the worldwide population and has a negative effect on patient quality of life. A variety of therapeutic approaches, e.g., glucocorticoid topical therapy, have shown limited efficacy with systemic adverse reactions. Therefore, novel therapeutic agents and physicochemical formulations are in constant need and should be obtained and tested in terms of effectiveness and minimization of side effects. For that reason, the aim of our study was to design and obtain various hybrid systems, nanoemulgel–macroemulsion and nanoemulgel–oleogel (bigel), as vehicles for ursolic acid (UA) and to verify their potential as topical formulations used in psoriasis treatment. Obtained topical formulations were characterized by conducting morphological, rheological, texture, and stability analysis. To determine the safety and effectiveness of the prepared ursolic acid carriers, in vitro studies on human keratinocyte cell-like HaCaT cells were performed with cytotoxicity analysis for individual components and each formulation. Moreover, a kinetic study of ursolic acid release from the obtained systems was conducted. All of the studied UA-loaded systems were well tolerated by keratinocyte cells and had suitable pH values and stability over time. The obtained formulations exhibit an apparent viscosity, ensuring the appropriate time of contact with the skin, ease of spreading, soft consistency, and adherence to the skin, which was confirmed by texture tests. The release of ursolic acid from each of the formulations is followed by a slow, controlled release according to the Korsmeyer–Peppas and Higuchi models. The elaborated systems could be considered suitable vehicles to deliver triterpene to psoriatic skin.
- Record ID
- CUTbd8048cf33c64319bf5863cd825e8fd2
- Publication categories
- ;
- Author
- Journal series
- Pharmaceutics, ISSN , e-ISSN 1999-4923, Monthly
- Issue year
- 2023
- Vol
- 15
- No
- 11
- Pages
- [1-28]
- Article number
- 2559
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 25-28; Bibliografia (liczba pozycji) - 93; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 15, Iss. 11
- Substantive notes
- This article belongs to the Special Issue: Advanced Bio-Hybrid Materials for Drug Delivery Systems - New Trends and Perspectives, 2nd Edition
- Keywords in English
- ursolic acid, nanoemulgel, hybrid systems, psoriasis, release kinetic
- ASJC Classification
- DOI
- DOI:10.3390/pharmaceutics15112559 Opening in a new tab
- URL
- https://www.mdpi.com/1999-4923/15/11/2559 Opening in a new tab
- Related project
- Opracowanie linii wyrobów medycznych na bazie nanożelu o właściwościach od pielęgnacyjnych po lecznicze, łagodzących stany zapalne skóry. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTbd8048cf33c64319bf5863cd825e8fd2/
- URN
urn:pkr-prod:CUTbd8048cf33c64319bf5863cd825e8fd2
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.