Nitro-functionalized analogues of 1,3-Butadiene: an overview of characteristic, synthesis, chemical transformations and biological activity
Authors:
- Mikołaj Sadowski,
- Karolina Kula
Abstract
The nitrovinyl moiety is surely one of the most reactive fragments in organic chemistry, continuously employed to explore original pathways and reach new targets. One of the most important classes of chemicals containing this fragment are nitro-functionalised analogues of 1,3-butadiene. In this paper a comprehensive review study of these compounds is performed. The manuscript includes an analysis of physicochemical properties, spectral characteristic, synthesis, biological activity, and possible transformations of nitro substituted analogues of 1,3butadiene. The analysis was divided into several parts, depending on the number of nitro groups included in the structure of a 1,3-butadiene analogue. In addition, the work includes information about hazards and safety principles when working with nitro compounds. Based on the analysis of the literature, it can be concluded that nitro-functionalised analogues of 1,3-butadiene exhibit diversified profile of properties, and an outstanding potential as valuable reagents in organic synthesis useful to obtain heterocycles that can be applied in medicine.
- Record ID
- CUT4503674d23804f35a123ac98167e0b6c
- Publication categories
- ;
- Author
- Journal series
- Current Chemistry Letters, ISSN 1927-7296, e-ISSN 1927-730X
- Issue year
- 2024
- Vol
- 13
- No
- 1
- Pages
- 15-30
- Other elements of collation
- rys.; schem.; tab.; wykr.; Bibliografia (na s.) - 28-30; Bibliografia (liczba pozycji) - 80; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 13, No. 1
- Keywords in English
- nitrobutadiene, synthesis, spectral characteristics, chemical transformation, biological activity
- DOI
- DOI:10.5267/j.ccl.2023.9.003 Opening in a new tab
- URL
- https://growingscience.com/ccl/Vol13/cclvol13Issue1.html Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 40
- Score source
- journalList
- Score
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT4503674d23804f35a123ac98167e0b6c/
- URN
urn:pkr-prod:CUT4503674d23804f35a123ac98167e0b6c
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.