Metal-organic frameworks for efficient drug adsorption and delivery
Authors:
- Kornelia Hyjek,
- Przemysław Jodłowski
Abstract
In recent years, the number of materials used as drug delivery systems (DDS) has increased dramatically. The widespread use of DDSs has improved both the safety and efficacy of therapy. The systems currently in use pose numerous drawbacks and require proper improvements. Although many modern materials are being developed, metal-organic frameworks (MOFs) deserve special attention. Thermal and chemical stability, high specific surface area, low toxicity, high biocompatibility, and great potential for modification are the main features enabling MOFs to be used as DDS. In this review, we describe MOFs, their structure, synthesis, and characterization, as well as drug loading, drug release kinetics, and bioassays. A critical approach is to outline the disadvantages as well as the limitations of MOFs and to identify areas that need to be studied more thoroughly. Nonetheless, the prospective nature of MOFs as DDS and potential adsorbents in overdose or poisoning is presented and highlighted.
- Record ID
- CUT31996866147d4a2997ec8b5f35b04b94
- Publication categories
- ;
- Author
- Journal series
- Scientiae Radices, ISSN 2956-4808
- Issue year
- 2023
- Vol
- 2
- No
- 2
- Pages
- 118-189
- Other elements of collation
- fot.; rys.; schem.; wykr.; Bibliografia (na s.) - 160-189; Bibliografia (liczba pozycji) - 291; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 2, Iss. 2
- Substantive notes
- Supporting information available online at https://sci-rad.com/wp-content/uploads/2023/06/scirad2023v2i2a03__supporting_information.pdf
- Keywords in English
- drug delivery systems, metal-organic frameworks, synthesis, characterization, drug loading, biocompatibility
- DOI
- DOI:10.58332/scirad2023v2i2a03 Opening in a new tab
- URL
- https://sci-rad.com/2023v2i2a03/ Opening in a new tab
- Related project
- MOF-antidote: Novel detoxification materials based on metal-organic frameworks for drugs of abuse removal – syn- thesis, chemical characterization, toxicity and efficacy in in vivo and in vitro studies. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 20
- Score source
- journalList
- Score
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT31996866147d4a2997ec8b5f35b04b94/
- URN
urn:pkr-prod:CUT31996866147d4a2997ec8b5f35b04b94
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.