Physicochemical and biological analysis of composite biomaterials containing hydroxyapatite for biological applications
Authors:
- Magdalena Bańkosz,
- Mateusz M. Urbaniak,
- Aleksandra Szwed,
- Karolina Rudnicka,
- Marcin Włodarczyk,
- Anna Drabczyk,
- Sonia Kudłacik-Kramarczyk,
- Bożena Tyliszczak,
- Agnieszka Sobczak-Kupiec
Abstract
Bone tissue regeneration is one of the main areas of tissue engineering. A particularly important aspect is the development of new innovative composite materials intended for bone tissue engineering and/or bone substitution. In this article, the synthesis and characterization of ceramic-polymer composites based on polyvinylpyrrolidone, poly(vinyl alcohol) and hydroxyapatite (HAp) have been presented. The first part of the work deals with the synthesis and characterization of the ceramic phase. It was demonstrated that the obtained calcium phosphate is characterized by a heterogeneity and porosity indicating simultaneously its large specific surface area. Additionally, in the wound healing test, it was shown that the obtained powder supports the regeneration of L929 cells. Next, HAp-containing composite materials were obtained in the wastefree photopolymerization process and characterized in detail. It was proved that the obtained composites were characterized by sorption properties and stability during 12-day incubation in simulated physiological liquids. Importantly, the obtained composites showed no cytotoxic effect against the L929 murine fibroblasts – the cell viability was 94.5%. Then, confocal microscopy allowed to observe that murine fibroblasts effectively colonized the surface of the obtained polymer-ceramic composites, covering the entire surface of the biomaterial. Thus, the obtained results confirm the high potential of the obtained composites in the application of bone tissue regenerative medicine.
- Record ID
- CUTfe58c198f3c5406db8ba48b285ff94a6
- Publication categories
- ;
- Author
- Journal series
- Journal of Biomedical Materials Research Part B-Applied Biomaterials, ISSN 1552-4973, e-ISSN 1552-4981
- Issue year
- 2023
- Vol
- 111
- No
- 12
- Pages
- 2077-2089
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 287-288; Bibliografia (liczba pozycji) - 43; Oznaczenie streszczenia - Abstr.; Data udostępnienia on-line - 2023-08-19; Numeracja w czasopiśmie - Vol. 111, Iss. 12
- Keywords in English
- cytotoxicity, hydroxyapatite, polymer-ceramic composites, sorption ability, wound healing assay
- ASJC Classification
- ;
- DOI
- DOI:10.1002/jbm.b.35309 Opening in a new tab
- URL
- https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35309 Opening in a new tab
- Related project
- Wielofunkcyjne kompozyty aktywne biologicznie do zastosowań w medycynie regeneracyjnej układu kostnego. . Project leader at PK: , ,
- Language
- eng (en) English
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTfe58c198f3c5406db8ba48b285ff94a6/
- URN
urn:pkr-prod:CUTfe58c198f3c5406db8ba48b285ff94a6
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.