The effect of filler content on mechanical properties and cell response of elastomeric PGS/apatite foam scaffolds
Authors:
- Paweł Piszko,
- Bartłomiej Kryszak,
- Małgorzata Gazińska,
- Dagmara Słota,
- Agnieszka Sobczak-Kupiec,
- Marcin Włodarczyk,
- Aleksandra Szwed-Georgiou,
- Karolina Rudnicka,
- Konrad Szustakiewicz
Abstract
Poly(glycerol sebacate) (PGS) is a novel polymeric material intended for applications in tissue engineering (TE). This study involves synthesizing the PGS prepolymer (pPGS) and subsequent manufacturing of porous PGS-based scaffolds with an addition of hydroxyapatite (HAp) by means of thermally induced phase separation followed by thermal cross-linking and salt-leaching (TIPS-TCL-SL). The study aims to investigate the effect of the apatite filler content on properties and morphology of porous PGS/HAp scaffolds. The emphasis is put on the mechanical behavior of the material characterized by means of compression tests and dynamic thermal mechanical analysis (DMTA). In addition to the reference polymer scaffold, the composites with filler contents of 10, 20 and 30 wt% have been examined. Our research revealed that the HAp content does not affect the mechanical properties in a directly proportional manner. The 30 wt% addition of HAp resulted in frayed structure and decrease in the mechanical parameters in comparison to other tested specimens. On the other hand, an addition of 10% did not sufficiently boost the properties. Therefore, a 20% addition of HAp was concluded to have superior mechanical properties in comparison to other analyzed specimens. A similar relationship results from the DMTA studies. Moreover, the strain sweep and frequency sweep tests confirmed the stability of the mechanical parameters in various conditions, as well as the elastomeric nature of the materials. Finally, the material did not exhibit cytotoxicity against standard L929 fibroblasts and cells readily populated the scaffolds.
- Record ID
- CUTa0ed69a57f9c4cb5a18e77d249c82abd
- Publication categories
- ;
- Author
- Journal series
- Ceramics International, ISSN 0272-8842, e-ISSN 1873-3956
- Issue year
- 2023
- Vol
- 49
- No
- 15
- Pages
- 25353-25363
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 25362-25363; Bibliografia (liczba pozycji) - 45; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 49, Iss. 15
- Keywords in English
- biocomposite, scaffold, poly(glycerol sebacate), tissue engineering, mechanical properties
- ASJC Classification
- ; ; ; ;
- DOI
- DOI:10.1016/j.ceramint.2023.05.071 Opening in a new tab
- URL
- https://www.sciencedirect.com/science/article/abs/pii/S0272884223013184 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 100
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTa0ed69a57f9c4cb5a18e77d249c82abd/
- URN
urn:pkr-prod:CUTa0ed69a57f9c4cb5a18e77d249c82abd
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.