Arylcyanomethylenequinone oximes: an overview of synthesis, chemical transformations, and biological activity
Authors:
- Karolina Kula,
- Roman Nagatsky,
- Mikołaj Sadowski,
- Yevheniia Siumka,
- Oleg M. Demchuk
Abstract
Quinone methides are a class of biologically active compounds that can be used in medicine as antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory agents. In addition, quinone methides have the potential to be used as pesticides, dyes, and additives for rubber and plastics. In this paper, we discuss a subclass of quinone methides: methylenequinone oximes. Although the first representatives of the subgroup were synthesized in the distant past, they still need to be additionally studied, while their chemistry, biological properties, and perspective of practical applications require to be comprehensively summarised. Based on the analysis of the literature, it can be concluded that methylenequinone oximes exhibit a diversified profile of properties and outstanding potential as new drug candidates and reagents in organic synthesis, both of electrophilic and nucleophilic nature, worthy of wide-ranging further research.
- Record ID
- CUT809efa548b514328ab453233ca393bbc
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2023
- Vol
- 28
- No
- 13
- Pages
- [1-26]
- Article number
- 5229
- Other elements of collation
- rys.; schem.; tab.; Bibliografia (na s.) - 22-26; Bibliografia (liczba pozycji) - 109; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 28, Iss. 13
- Substantive notes
- This article belongs to the Special Issue Feature Papers in Organic Chemistry (Volume II)
- Keywords in English
- quinonemethide, arylcyanomethylenequinone oximes, quinone, chemical transformation, biological activity
- ASJC Classification
- DOI
- DOI:10.3390/molecules28135229 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/28/13/5229 Opening in a new tab
- Related project
- Opracowanie fotoaktywowalnych cząsteczek o aktywności przeciwnowotworowej i przeciwgrzybiczej, stanowiących koniugaty metydów chinonów, leków przeciwnowotworowych i nanocząstek złota, o potencjale terapeutycznym wobec nowotworów pęcherza moczowego. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT809efa548b514328ab453233ca393bbc/
- URN
urn:pkr-prod:CUT809efa548b514328ab453233ca393bbc
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.