Clindamycin-loaded nanosized calcium phosphates powders as a carrier of active substances
Authors:
- Dagmara Słota,
- Karina Piętak,
- Wioletta Florkiewicz,
- Josef Jampilek,
- Agnieszka Tomala,
- Mateusz M. Urbaniak,
- Agata Tomaszewska,
- Karolina Rudnicka,
- Agnieszka Sobczak-Kupiec
Abstract
Bioactive calcium phosphate ceramics (CaPs) are one of the building components of the inorganic part of bones. Synthetic CaPs are frequently used as materials for filling bone defects in the form of pastes or composites; however, their porous structure allows modification with active substances and, thus, subsequent use as a drug carrier for the controlled release of active substances. In this study, four different ceramic powders were compared: commercial hydroxyapatite (HA), TCP, brushite, as well as HA obtained by wet precipitation methods. The ceramic powders were subjected to physicochemical analysis, including FTIR, XRD, and determination of Ca/P molar ratio or porosity. These techniques confirmed that the materials were phase-pure, and the molar ratios of calcium and phosphorus elements were in accordance with the literature. This confirmed the validity of the selected synthesis methods. CaPs were then modified with the antibiotic clindamycin. Drug release was determined on HPLC, and antimicrobial properties were tested against Staphylococcus aureus. The specific surface area of the ceramic has been demonstrated to be a factor in drug release efficiency.
- Record ID
- CUT1f8a3201f46e493cbddd61ec22d8f9e1
- Publication categories
- ;
- Author
- Journal series
- Nanomaterials, ISSN , e-ISSN 2079-4991, Biweekly
- Issue year
- 2023
- Vol
- 13
- No
- 9
- Pages
- [1-19]
- Article number
- 1469
- Other elements of collation
- fot.; rys.; tab.; wykr.; Bibliografia (na s.) - 16-19; Bibliografia (liczba pozycji) - 65; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 13, Iss. 9
- Substantive notes
- This article belongs to the Special Issue: Feature Papers in Nanomaterials Science
- Keywords in English
- calcium phosphates, ceramics, hydroxyapatite, brushite, drug delivery system, antibiotic, clindamycin
- DOI
- DOI:10.3390/nano13091469 Opening in a new tab
- URL
- https://www.mdpi.com/2079-4991/13/9/1469 Opening in a new tab
- Related project
- Wielofunkcyjne kompozyty aktywne biologicznie do zastosowań w medycynie regeneracyjnej układu kostnego. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 100
- Score source
- journalList
- Score
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT1f8a3201f46e493cbddd61ec22d8f9e1/
- URN
urn:pkr-prod:CUT1f8a3201f46e493cbddd61ec22d8f9e1
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.