The global and local reactivity of C,N-diarylnitryle imines in [3+2] cycloaddition processes with trans-β-nitrostyrene according to Molecular Electron Density Theory: A computational study
Authors:
- Mikołaj Sadowski,
- Jolanta Utnicka,
- Adrianna Wójtowicz,
- Karolina Kula
Abstract
The regioselectivity of the [3+2] cycloaddition reactions between trans-β-nitrostyrene and C,Ndiarylnitryle imine analogues as three atom components (TACs) has been studied with the use of Conceptual Density Functional Theory in the framework of Molecular Electron density Theory. Global and local reactivity indices were determined. Presented quantum-chemical computations showed that, for the reaction of nitroalkene with diphenylnitryle imine, the most favourable reaction path is determined by the nucleophilic attack of C3 carbon atom of TAC on an electrophilic Cα carbon atom of nitroalkene. Therefore, the creation of 1,3,4-triphenyl-5-nitroΔ2 -pyrazoline, according to channel B, is more probable. Similarly, to presented conclusion, for reactions of nitroalkene with nitryle imines containing an ED group at para position of the phenyl ring also the most favourable reaction paths run through channel B leading to 1,3,4-triaryl-5nitro-Δ2 -pyrazolines. In turn, reactions of nitroalkene with nitryle imines containing an EW group at para position of the phenyl ring have the opposite preference and the most favourable reaction paths is channel A leading to 1,3,5-triaryl-4-nitro-Δ2 -pyrazolines.
- Record ID
- CUTb8c1c74e1e4c448ca60ce5194f5b2784
- Publication categories
- ;
- Author
- Journal series
- Current Chemistry Letters, ISSN 1927-7296, e-ISSN 1927-730X
- Issue year
- 2023
- Vol
- 12
- No
- 2
- Pages
- 421-430
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 428-430; Bibliografia (liczba pozycji) - 53; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 12, Iss. 2
- Keywords in English
- conceptual density functional, molecular electron density, nitrilimine, regioselectivity, theory, theory, [3+2] cycloaddition reaction
- DOI
- DOI:10.5267/j.ccl.2022.11.004 Opening in a new tab
- URL
- http://growingscience.com/beta/ccl/5877-the-global-and-local-reactivity-of-cn-diarylnitryle-imines-in-32-cycloaddition-processes-with-trans-nitrostyrene-according-to-molecular-electron-density-theory-a-computational-study.html Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 40
- Score source
- journalList
- Score
- Additional fields
- Indeksowana w: Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTb8c1c74e1e4c448ca60ce5194f5b2784/
- URN
urn:pkr-prod:CUTb8c1c74e1e4c448ca60ce5194f5b2784
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.