Hydrogel-like polymeric materials obtained in situ by visible-light initiated photopolymerization using novel photoinitiating systems
Authors:
- Katarzyna Starzak,
- Wiktoria Tomal,
- Joanna Ortyl
Abstract
Hydrogel materials due to their unique properties such as high porosity, non-toxicity, high rate of reversible fluid absorption or good mechanical strength and because their structural and biochemical properties are similar to those of the extracellular matrix (ECM) in most tissues make them ideal for applications in the biomedical industry, especially in tissue engineering. Additional use of materials of natural origin for their production increases their biocompatibility and is consistent with the principles of green chemistry. One of the most important methods to obtain hydrogel materials are in situ photopolymerization processes. An example of such a process can be radical photopolymerization consisting of initiation, propagation and termination steps. It also provides the possibility of spatiotemporal control of the polymerization process. The proposed method, from the economical point of view, is extremely energy efficient because it is photochemically initiated, so its time is counted in seconds and the whole process is carried out at ambient temperature. Therefore, the development of new photoinitiating systems, effective in the visible light range and characterized by solubility in an aqueous environment, is crucial for the efficient and safe production of hydrogel materials. In the present work, new organic chromophores formed in the synthesis of citric acid with various amines have been proposed as effective photosensitizers of iodonium salt. The resulting TPA (5-oxo-2,3dihydrothiazolo[3,2-a]pyridine-3,7-dicarboxylic acid) and CATF (2,3,4,4a-tetrahydropyrido[2,1b][1,3]benzothiazol-1-one;(E)-2-vinylbut-2-enoic acid) chromophores together with iodonium salt form an efficient and effective binary photoinitiating system for photopolymerization processes, including radical polymerization. A complete spectroscopic, electrochemical and thermodynamic characterization of the new two-component photoinitiating systems was carried out. The kinetics of the hydrogel material formation process was monitored using the real-time FT-IR technique, which enabled the monitoring of the photopolymerization process. In this way, an efficient way to obtain hydrogel polymeric materials was developed. An additional feature allowing a more accurate observation of the properties and behavior of the obtained materials is the fluorescence of the fluorophore used.
- Record ID
- CUT6c07a6c65e124de99a688430ebf7354c
- Publication categories
- ; ;
- Author
- Pages
- [159]
- Substantive notes
- Sesja: Medicinal Chemistry
- Miejsce wyd. i miejsce konf. wg siedziby org.
- Wydawca wg org. konf.
- Data wyd. wg daty konf.
- Book
- AMYC-BIOMED 2021 : 2nd Autumn Meeting for Young Chemists in Biomedical Sciences, 3-5 November 2021 – virtual conference : e-book of abstracts, 2021, [Naples], University of Naples Federico II, ISBN 978-88-94952-19-3
- Keywords in English
- hydrogel, photopolymerization, photoinitiating systems, polymer materials
- URL
- https://amyc-biomed-2021.webnode.it/chi-siamo/ Opening in a new tab
- Related project
- Molecular desing, synthesis and application of photoinitiator-catalysts (PICs) for photopolymerization reactions. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 0
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT6c07a6c65e124de99a688430ebf7354c/
- URN
urn:pkr-prod:CUT6c07a6c65e124de99a688430ebf7354c
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