Are natural compounds a promising alternative to synthetic cross-linking agents in the preparation of hydrogels?
Authors:
- Paulina Sapuła,
- Katarzyna Bialik-Wąs,
- Katarzyna Malarz
Abstract
The main aim of this review is to assess the potential use of natural cross-linking agents, such as genipin, citric acid, tannic acid, epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for the biomedical, pharmaceutical, and cosmetic industries. Chemical cross-linking is one of the most important methods that is commonly used to form mechanically strong hydrogels based on biopolymers, such as alginates, chitosan, hyaluronic acid, collagen, gelatin, and fibroin. Moreover, the properties of natural cross-linking agents and their advantages and disadvantages are compared relative to their commonly known synthetic cross-linking counterparts. Nowadays, advanced technologies can facilitate the acquisition of high-purity biomaterials from unreacted components with no additional purification steps. However, while planning and designing a chemical process, energy and water consumption should be limited in order to reduce the risks associated with global warming. However, many synthetic cross-linking agents, such as N,N’-methylenebisacrylamide, ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylates, epichlorohydrin, and glutaraldehyde, are harmful to both humans and the environment. One solution to this problem could be the use of bio-cross-linking agents obtained from natural resources, which would eliminate their toxic effects and ensure the safety for humans and the environment.
- Record ID
- CUT438f9bfe9c7c4893ae6f41750de58cd4
- Publication categories
- ;
- Author
- Journal series
- Pharmaceutics, ISSN , e-ISSN 1999-4923, Monthly
- Issue year
- 2023
- Vol
- 15
- No
- 1
- Pages
- [1-38]
- Article number
- 253
- Other elements of collation
- rys.; schem.; tab.; Bibliografia (na s.) - 29-38; Bibliografia (liczba pozycji) - 242; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 15, Iss. 1
- Substantive notes
- Special Issue: Advanced Bio-Hybrid Materials for Drug Delivery Systems - New Trends and Perspectives
- Keywords in English
- natural and synthetic cross-linking agents, hydrogels, biocompatibility, environmental protection
- ASJC Classification
- DOI
- DOI:10.3390/pharmaceutics15010253 Opening in a new tab
- URL
- https://www.mdpi.com/1999-4923/15/1/253 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT438f9bfe9c7c4893ae6f41750de58cd4/
- URN
urn:pkr-prod:CUT438f9bfe9c7c4893ae6f41750de58cd4
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.