Acridine as an anti-tumour agent: a critical review
Authors:
- Potlapati Varakumar,
- Kalirajan Rajagopal,
- Baliwada Aparna,
- Kannan Raman,
- Gowramma Byran,
- Clara Mariana Gonçalves Lima,
- Salma Rashid,
- Mohammed H. Nafady,
- Talha Bin Emran,
- Sławomir Wybraniec
Abstract
This review summarized the current breakthroughs in the chemistry of acridines as anticancer agents, including new structural and biologically active acridine attributes. Acridine derivatives are a class of compounds that are being extensively researched as potential anti-cancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is restricted or even excluded as a result of side effects. The photocytotoxicity of propyl acridine acts against leukaemia cell lines, with C1748 being a promising anti-tumour drug against UDPUGT’s. CK0403 is reported in breast cancer treatment and is more potent than CK0402 against estrogen receptor-negative HER2. Acridine platinum (Pt) complexes have shown specificity on the evaluated DNA sequences; 9-anilinoacridine core, which intercalates DNA, and a methyl triazene DNA-methylating moiety were also studied. Acridine thiourea gold and acridinone derivatives act against cell lines such as MDA-MB-231, SK-BR-3, and MCF-7. Benzimidazole acridine compounds demonstrated cytotoxic activity against Dual Topo and PARP-1. Quinacrine, thiazacridine, and azacridine are reported as anti-cancer agents, which have been reported in the previous decade and were addressed in this review article.
- Record ID
- CUT47594cebb2a24d4e810c6847004be040
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2023
- Vol
- 28
- No
- 1
- Pages
- [1-42]
- Article number
- 193
- Other elements of collation
- rys.; schem.; tab.; Bibliografia (na s.) - 37-42; Bibliografia (liczba pozycji) - 97; Oznaczenie streszczenia - Abstr.; Data udostępnienia on-line - 2022-12-26; Numeracja w czasopiśmie - Vol. 28, Iss. 1
- Substantive notes
- Special Issue: Design, Synthesis and Evaluation of Novel Anticancer Agents
- Keywords in English
- acridine, anti-cancer, cancer cell lines, DNA-intercalation, topoisomerase, in vitro assay
- ASJC Classification
- DOI
- DOI:10.3390/molecules28010193 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/28/1/193 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT47594cebb2a24d4e810c6847004be040/
- URN
urn:pkr-prod:CUT47594cebb2a24d4e810c6847004be040
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.