Impact of electrospinning parameters and post-treatment method on antibacterial and antibiofilm activity of chitosan nanofibers
Authors:
- Viktoriia Korniienko,
- Yevheniia Husak,
- Julia Radwan-Pragłowska,
- Viktoriia Holubnycha,
- Yevhen Samokhin,
- Anna Yanovska,
- Julia Varava,
- Kateryna Diedkova,
- Łukasz Janus,
- Pogorielov Maksym
Abstract
Chitosan, a natural biopolymer, is an ideal candidate to prepare biomaterials capable of preventing microbial infections due to its antibacterial properties. Electrospinning is a versatile method ideally suited to process biopolymers with minimal impact on their physicochemical properties. However, fabrication parameters and post-processing routine can affect biological activity and, therefore, must be well adjusted. In this study, nanofibrous membranes were prepared using trifluoroacetic acid and dichloromethane and evaluated for physiochemical and antimicrobial properties. The use of such biomaterials as potential antibacterial agents was extensively studied in vitro using Staphylococcus aureus and Escherichia coli as test organisms. The antibacterial assay showed inhibition of bacterial growth and eradication of the planktonic cells of both E. coli and S. aureus in the liquid medium for up to 6 hrs. The quantitative assay showed a significant reduction in bacteria cell viability by nanofibers depending on the method of fabrication. The antibacterial properties of these biomaterials can be attributed to the structural modifications provided by co-solvent formulation and application of post-treatment procedure. Consequently, the proposed antimicrobial surface modification method is a promising technique to prepare biomaterials designed to induce antimicrobial resistance via antiadhesive capability and the biocide-releasing mechanism.
- Record ID
- CUT600c8649300446778ee606d0c2fdcfae
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2022
- Vol
- 27
- No
- 10
- Pages
- [1-14]
- Article number
- 3343
- Other elements of collation
- fot.; schem.; tab.; wykr.; Bibliografia (na s.) - 13-14; Bibliografia (liczba pozycji) - 36; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 27, Iss. 10
- Substantive notes
- Special Issue: Natural Products with Biological and Therapeutic Activity
- Keywords in English
- natural products, chitosan electrospinning, antibacterial biomaterials
- ASJC Classification
- DOI
- DOI:10.3390/molecules27103343 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/27/10/3343 Opening in a new tab
- Related project
- BioHemPro - personalizowane bifunkcyjne matryce hybrydowe o indukowanych właściwościach bioaktywnych jako innowacyjne systemy hemostatyczne. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Nanostructural surface development for dental implant manufacturing. . Project leader at PK: , ,
- BioHemPro - personalizowane bifunkcyjne matryce hybrydowe o indukowanych właściwościach bioaktywnych jako innowacyjne systemy hemostatyczne. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT600c8649300446778ee606d0c2fdcfae/
- URN
urn:pkr-prod:CUT600c8649300446778ee606d0c2fdcfae
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.