Liposomes as biocompatible and smart delivery systems – the current state
Authors:
- Michał Dymek,
- Elżbieta Sikora
Abstract
Liposomes are self-assembled, closed spherical systems, composed of one or more amphiphilic phospholipids, and widely used in the pharmaceutical, cosmetic and food industries. Whether composed of natural or synthetic phospholipids, liposomal vehicles are biocompatible, biodegradable, non-toxic and non-immunogenic carriers of active substances, both hydrophilic and hydrophobic by nature. Progress in liposome technology, modulation of the lipid composition, size and charge of the vesicle and modification of their surface has enabled the shift from conventional vesicles to "smart-generation" liposomes. Currently, liposomal vesicles are applied to improve the therapeutic effect of active substances and to provide the controlled release of drugs, thus prolonging the biological half-life or reducing toxicity of the actives. This paper reviews the recent process developments in liposomal systems, especially over the past decade. The methods of the systems preparation, characterisation and application are described. Additionally, methods of liposome surface modification and the mechanism of active substances delivery are outlined.
- Record ID
- CUT2f0e406401ca4a25a8e9ee90623ed478
- In press
- Yes
- Publication categories
- ;
- Author
- Journal series
- Advances in Colloid and Interface Science, ISSN 0001-8686, e-ISSN 1873-3727
- Issue year
- 2022
- Pages
- [1-36]
- Article number
- 102757
- Other elements of collation
- rys.; tab.; Bibliografia (na s.) - [18-29]; Bibliografia (liczba pozycji) - 197; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Article in press, Spec. Iss.
- Substantive notes
- Special Issue in Honor of the 70th Birthday of Professor Zbigniew Adamczyk
- Keywords in English
- liposomes, liposome preparation, active substances, smart delivery systems
- ASJC Classification
- ; ;
- DOI
- DOI:10.1016/j.cis.2022.102757 Opening in a new tab
- URL
- https://www.sciencedirect.com/science/article/pii/S0001868622001592 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 200
- Score source
- journalList
- Score
- Publication indicators
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT2f0e406401ca4a25a8e9ee90623ed478/
- URN
urn:pkr-prod:CUT2f0e406401ca4a25a8e9ee90623ed478
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.