Bio-hybrid hydrogels incorporated into a system of salicylic acid-pH/thermosensitive nanocarriers intended for cutaneous wound-healing processes
Authors:
- Katarzyna Bialik-Wąs,
- Małgorzata Miastkowska,
- Paulina Sapuła,
- Klaudia Pluta,
- Dagmara Malina,
- Jarosław Chwastowski,
- Mateusz Barczewski
Abstract
In this paper, the preparation method of bio-hybrid hydrogels incorporated into a system of salicylic acid-pH/thermosensitive nanocarriers to speed up the wound-healing process was developed. This combination creates a dual drug delivery system, which releases the model hydrophobic active substance—salicylic acid—in a gradual and controlled manner for an extended time. Our research team has determined the various properties of bio-hybrid hydrogels based on their physicochemical (swelling degree, and degradation), structural (FT-IR), morphological (SEM), and mechanical (elongation tests) traits. Moreover, empty pH/thermosensitive nanocarriers and their salicylic acid-containing systems were characterized using the following methods: DLS, TG/DTG, and DSC. Additionally, salicylic acid release profiles directly from thermosensitive nanocarriers were compared to the bio-hybrid matrix. These studies were conducted in PBS (pH = 7.4) for 7 days using the USP4 method. To evaluate the antibacterial properties of the obtained materials, the inhibition of growth of Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger—as the main microorganisms responsible for human infections—were tested. The obtained results indicated that the pH/thermosensitive nanocarrier–salicylic acid system and bio-hybrid hydrogels are characterized by antibacterial activity against both S. aureus and E. coli.
- Record ID
- CUTc4c5914d8d854399816240a27248ff7b
- Publication categories
- ;
- Author
- Journal series
- Pharmaceutics, ISSN , e-ISSN 1999-4923, Monthly
- Issue year
- 2022
- Vol
- 14
- No
- 4
- Pages
- [1-22]
- Article number
- 773
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 19-22; Bibliografia (liczba pozycji) - 77; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 14, Iss. 4, Spec. Iss.
- Substantive notes
- Special Issue: Advanced Bio-Hybrid Materials for Drug Delivery Systems - New Trends and Perspectives
- Supplementary Materials are available online at https://www.mdpi.com/article/10.3390/pharmaceutics14040773/s1
- Keywords in English
- bio-hybrid hydrogels, salicylic acid, pH/thermosensitive nanocarriers, drug release, USP4 method
- ASJC Classification
- DOI
- DOI:10.3390/pharmaceutics14040773 Opening in a new tab
- URL
- https://www.mdpi.com/1999-4923/14/4/773 Opening in a new tab
- Related project
- Opracowanie metody otrzymywania bio-hybrydowych materiałów hydrożelowych inkorporowanych systemem nanonośnik-lek jako wielokompartmentowych opatrunków umożliwiających leczenie Psoriasis. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- License
- Score (nominal)
- 100
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTc4c5914d8d854399816240a27248ff7b/
- URN
urn:pkr-prod:CUTc4c5914d8d854399816240a27248ff7b
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.