Novel Synthesis, characterization and amoxicillin release study of pH-sensitive Nanosilica/Poly(acrylic acid) macroporous hydrogel with high swelling
Authors:
- Tannaz Soltanolzakerin Sorkhabi,
- Mehrab Fallahi Samberan,
- Krzysztof Adam Ostrowski,
- Tomasz M. Majka
Abstract
The effect of SiO2 nanoparticles on the formation of PAA (poly acrylic acid) gel structure was investigated with seeded emulsion polymerization method used to prepare SiO2/PAA nanoparticles. The morphologies of the nanocomposite nanoparticles were studied by transmission electron microscopy (TEM). Fourier-transform infrared (FTIR) spectroscopy results indicated that the PAA was chemically bonded to the surface of the SiO2 nanoparticles. Additionally, the resulting morphology of the nanocomposite nanoparticles confirmed the co-crosslinking role of the SiO2 nanoparticles in the formation of the 3D structure and hydrogel of PAA. SiO2/PAA nanocomposite hydrogels were synthesized by in situ solution polymerization with and without toluene. The morphology studies by field emission scanning electron microscopy (FESEM) showed that when the toluene was used as a pore forming agent in the polymerization process, a macroporous hydrogel structure was achieved. The pH-sensitive swelling behaviors of the nanocomposite hydrogels showed that the formation of pores in the gels structure was a dominant factor on the water absorption capacity. In the current research the absorption capacity was changed from about 500 to 4000 g water/g dry hydrogel. Finally, the macroporous nanocomposite hydrogel sample was tested as an amoxicillin release system in buffer solutions with pHs of 3, 7.2, and 9 at 37 ◦C. The results showed that the percentage cumulative release of amoxicillin from the hydrogels was higher in neutral and basic mediums than in the acidic medium and the amoxicillin release rate was decreased with increasing pH. Additionally, the release results were very similar to swelling results and hence amoxicillin release was a swelling controlled-release system.
- Record ID
- CUTded8543476c94a71bbf09274b051b043
- Publication categories
- ;
- Author
- Journal series
- Materials, ISSN , e-ISSN 1996-1944, Biweekly
- Issue year
- 2022
- Vol
- 15
- No
- 2
- Pages
- [1-13]
- Article number
- 469
- Other elements of collation
- fot.; rys.; wykr.; Bibliografia (na s.) - 11-13; Bibliografia (liczba pozycji) - 36; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 15, Iss. 2, Spec. Iss.
- Substantive notes
- Special Issue: Polymer-Based Nanoparticles for Drug Delivery Applications
- Keywords in English
- poly(acrylic acid), macroporous hydrogel, nanocomposite, high swelling ratio, drug delivery, amoxicillin
- ASJC Classification
- DOI
- DOI:10.3390/ma15020469 Opening in a new tab
- URL
- https://www.mdpi.com/1996-1944/15/2/469 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Score source
- journalList
- Score
- Publication indicators
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTded8543476c94a71bbf09274b051b043/
- URN
urn:pkr-prod:CUTded8543476c94a71bbf09274b051b043
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.