Physicochemical characteristics of chitosan-based hydrogels containing albumin particles and aloe vera juice as transdermal systems functionalized in the viewpoint of potential biomedical applications
Authors:
- Sonia Kudłacik-Kramarczyk,
- Magdalena Głąb,
- Anna Drabczyk,
- Aleksandra Kordyka,
- Marcin Godzierz,
- Paweł S. Wróbel,
- Marcel Krzan,
- Marimuthu Uthayakumar,
- Magdalena Kędzierska,
- Bożena Tyliszczak
Abstract
In recent years, many investigations on the development of innovative dressing materials with potential applications, e.g., for cytostatics delivery, have been performed. One of the most promising carriers is albumin, which tends to accumulate near cancer cells. Here, chitosan-based hydrogels containing albumin spheres and Aloe vera juice, designed for the treatment of skin cancers or burn wounds resulting from radiotherapy, were developed. The presence of albumin in hydrogel matrices was confirmed via Fourier transform infrared (FT-IR) and Raman spectroscopy. Albumin spheres were clearly visible in microscopic images. It was proved that the introduction of albumin into hydrogels resulted in their increased resistance to the tensile load, i.e., approximately 30% more force was needed to break such materials. Modified hydrogels showed approximately 10% more swelling ability. All hydrogels were characterized by hydrophilicity (contact angles were <90) which may support the regeneration of epithelial cells and non-cytotoxicity towards murine fibroblasts L929 and released Aloe vera juice more effectively in an acidic environment than in a neutral one wherein spheres introduced into the hydrogel matrix extended the release time. Thus, the developed materials, due to their chemical composition and physicochemical properties, constitute promising materials with great application potential for biomedical purposes.
- Record ID
- CUTfe02d60d01be458d91de6ed27f24349b
- Publication categories
- ;
- Author
- Journal series
- Materials, ISSN , e-ISSN 1996-1944, Biweekly
- Issue year
- 2021
- Vol
- 14
- No
- 19
- Pages
- [1-26]
- Article number
- 5832
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 25-26; Bibliografia (liczba pozycji) - 39; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 14, Iss. 19, Spec. Iss.
- Substantive notes
- Special Issue: Advanced Biomedical Hydrogels and Bioactive Materials in Medicinal Chemistry
- Keywords in English
- chitosan hydrogels, albumin particles, aloe vera juice, wettability, tensile load, swelling ability, hydrogel dressings
- DOI
- DOI:10.3390/ma14195832 Opening in a new tab
- URL
- https://www.mdpi.com/1996-1944/14/19/5832 Opening in a new tab
- Related project
- Zastosowanie Beetosanu do otrzymywania nowoczesnych biomedycznych matryc hydrożelowych. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - E-mobilność oraz zrównoważone materiały i technologie. . Project leader at PK: , ,
- Otrzymywanie sfer polimerowych na bazie albuminy z inkorporowaną substancją aktywną. . Project leader at PK: , ,
- Zastosowanie Beetosanu do otrzymywania nowoczesnych biomedycznych matryc hydrożelowych. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Publication indicators
- = 13
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTfe02d60d01be458d91de6ed27f24349b/
- URN
urn:pkr-prod:CUTfe02d60d01be458d91de6ed27f24349b
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.