Starch solutions prepared under different conditions as modifiers of chitosan/poly(aspartic acid)-based hydrogels
Authors:
- Magdalena Głąb,
- Anna Drabczyk,
- Sonia Kudłacik-Kramarczyk,
- Martin Duarte Guigou,
- Agnieszka Makara,
- Paweł Gajda,
- Josef Jampilek,
- Bożena Tyliszczak
Abstract
Recently, there has been great interest in the application of polysaccharides in the preparation of diverse biomaterials which result from their biocompatibility, biodegradability and biological activity. In this work, the investigations on chitosan/poly(aspartic acid)-based hydrogels modified with starch were described. Firstly, a series of hydrogel matrices was prepared and investigated to characterize their swelling properties, structure via FT-IR spectroscopy, elasticity and tensile strength using the Brookfield texture analyzer as well as their impact on simulated physiological liquids. Hydrogels consisting of chitosan and poly(aspartic acid) in a 2:1 volume ratio were elastic (9% elongation), did not degrade after 30-day incubation in simulated physiological liquids, exhibited a relative biocompatibility towards these liquids and similar swelling in each absorbed medium. This hydrogel matrix was modified with starch wherein two of its form were applied—a solution obtained at an elevated temperature and a suspension obtained at room temperature. Hydrogels modified with hot starch solution showed higher sorption that unmodified materials. This was probably due to the higher starch inclusion (i.e., a larger number of hydrophilic groups able to interact with the adsorbed liquid) when this polysaccharide was given in the form of a hot solution. Hydrogels modified with a cold starch suspension had visible heterogeneous inequalities on their surfaces and this modification led to the obtainment materials with unrepeatable structures which made the analysis of their properties difficult and may have led to misleading conclusions.
- Record ID
- CUT1adaf8893eb04a09bf29e6cdeb579198
- Publication categories
- ;
- Author
- Journal series
- Materials, ISSN , e-ISSN 1996-1944, Biweekly
- Issue year
- 2021
- Vol
- 14
- No
- 16
- Pages
- [1-18]
- Article number
- 4443
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 17-18; Bibliografia (liczba pozycji) - 33; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 14, Iss. 16, Spec. Iss.
- Substantive notes
- Special Issue: Advanced Biomedical Hydrogels and Bioactive Materials in Medicinal Chemistry
- Keywords in English
- chitosan, starch, poly(aspartic acid), polysaccharides, hydrogels, tensile strength, swelling ability, simulated physiological liquids
- DOI
- DOI:10.3390/ma14164443 Opening in a new tab
- URL
- https://www.mdpi.com/1996-1944/14/16/4443 Opening in a new tab
- Related project
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Publication indicators
- = 2
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT1adaf8893eb04a09bf29e6cdeb579198/
- URN
urn:pkr-prod:CUT1adaf8893eb04a09bf29e6cdeb579198
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.