Hydroxyapatite obtained via the wet precipitation method and PVP/PVA matrix as components of polymer-ceramic composites for biomedical applications
Authors:
- Magdalena Głąb,
- Sonia Kudłacik-Kramarczyk,
- Anna Drabczyk,
- Janusz Walter,
- Aleksandra Kordyka,
- Marcin Godzierz,
- Rafał Bogucki,
- Bożena Tyliszczak,
- Agnieszka Sobczak-Kupiec
Abstract
The aspect of drug delivery is significant in many biomedical subareas including tissue engineering. Many studies are being performed to develop composites with application potential for bone tissue regeneration which at the same provide adequate conditions for osteointegration and deliver the active substance conducive to the healing process. Hydroxyapatite shows a great potential in this field due to its osteoinductive and osteoconductive properties. In the paper, hydroxyapatite synthesis via the wet precipitation method and its further use as a ceramic phase of polymer– ceramic composites based on PVP/PVA have been presented. Firstly, the sedimentation rate of hydroxyapatite in PVP solutions has been determined, which allowed us to select a 15% PVP solution (sedimentation rate was 0.0292 mm/min) as adequate for preparation of homogenous reaction mixture treated subsequently with UV radiation. Both FT-IR spectroscopy and EDS analysis allowed us to confirm the presence of both polymer and ceramic phase in composites. Materials containing hydroxyapatite showed corrugated and well-developed surface. Composites exhibited swelling properties (hydroxyapatite reduced this property by 25%) in simulated physiological fluids, which make them useful in drug delivery (swelling proceeds parallel to the drug release). The short synthesis time, possibility of preparation of composites with desired shapes and sizes and determined physicochemical properties make the composites very promising for biomedical purposes.
- Record ID
- CUTa214df2a4a6b41bf82984783ed214c57
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2021
- Vol
- 26
- No
- 14
- Pages
- [1-18]
- Article number
- 4268
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 16-18; Bibliografia (liczba pozycji) - 41; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 26, Iss. 14, Spec. Iss.
- Substantive notes
- Special Issue: Polymer Molecules and Biopolymers in Drug Delivery
- Keywords in English
- hydroxyapatite, polymer-ceramic composites, PVP/PVA-based polymers, sedimentation rate, sorption capability, tissue engineering
- DOI
- DOI:10.3390/molecules26144268 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/26/14/4268 Opening in a new tab
- Related project
- Wielofunkcyjne kompozyty aktywne biologicznie do zastosowań w medycynie regeneracyjnej układu kostnego. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Publication indicators
- = 17
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTa214df2a4a6b41bf82984783ed214c57/
- URN
urn:pkr-prod:CUTa214df2a4a6b41bf82984783ed214c57
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.