Multistep chemical processing of crickets leading to the extraction of chitosan used for synthesis of polymer drug carriers
Authors:
- Magdalena Głąb,
- Sonia Kudłacik-Kramarczyk,
- Anna Drabczyk,
- Martin Duarte Guigou,
- Agnieszka Sobczak-Kupiec,
- Dariusz Mierzwiński,
- Paweł Gajda,
- Janusz Walter,
- Bożena Tyliszczak
Abstract
Chitosan belongs to the group of biopolymers with increasing range of potential applications therefore searching for new raw materials as well as new techniques of obtaining of this polysaccharide are currently a subject of interest of many scientists. Presented manuscript describes preparation of chitosan from crickets. Obtainment of final product required a number of processes aimed at removal of undesirable substances such as waxes, mineral salts, proteins or pigments from above-mentioned insects. Chemical structure of fractions obtained after each step was compared with the structure of commercial chitosan by means of techniques such as X-ray diffraction and FT-IR spectroscopy. Final product was subsequently used for preparation of polymer capsules that were modified with active substance characterized by antibacterial and anticancer activity—nisin. Next, sorption capacity of obtained materials was evaluated as well as a release profile of active substance in different environments. Based on the conducted research it can be concluded that crickets constitute an alternative for shellfish and other conventional sources of chitosan. Furthermore, obtained capsules on the basis of such prepared chitosan can be considered as drug delivery systems which efficiency of release of active substance is bigger in alkaline environments.
- Record ID
- CUT82182266a7614b219516e78279381160
- Publication categories
- ;
- Author
- Journal series
- Materials, ISSN , e-ISSN 1996-1944, Biweekly
- Issue year
- 2021
- Vol
- 14
- No
- 17
- Pages
- [1-20]
- Article number
- 5070
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 19-20; Bibliografia (liczba pozycji) - 41; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 14, Iss. 17, Spec. Iss.
- Substantive notes
- Tyt. Spec. Iss. : Advanced Biomedical Hydrogels and Bioactive Materials iin Medicinal Chemistry
- Keywords in English
- chitosan, drug delivery systems, nisin, polymer capsules
- DOI
- DOI:10.3390/ma14175070 Opening in a new tab
- URL
- https://www.mdpi.com/1996-1944/14/17/5070 Opening in a new tab
- Related project
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Publication indicators
- = 3
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT82182266a7614b219516e78279381160/
- URN
urn:pkr-prod:CUT82182266a7614b219516e78279381160
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.