Nanostructured hemostatic sponges made from chitosan : structural and biological evaluation
Authors:
- J. Radwan-Pragłowska,
- V. Korniienko,
- Ye. Husak,
- V. Deineka,
- Ł. Janus,
- D. Matysek,
- V. Holubnycha,
- O. Oleshko,
- M. Piątkowski,
- M. Pogorielov
Abstract
Local hemostatic agents are a necessary element of surgical work that reduces blood loss and mortality. Despite the variety of materials, there is no perfect styptic. The most promising hemostatic agents are based on biomaterials therefore they can be left in the wound. The aim of the following research was to obtain a new type of biocompatible chitosan-based agents with high hemostatic activity. The biomaterials were obtained under microwave radiation using l-aspartic acid, l-glutamic acid as crosslinking agents. Chitosan sponges showed high porosity and antioxidant activity, and also high antibacterial activity against both S. aureus and to E. coli. This material was absolutely non-toxic on cell culture and showed good hemostatic properties after interaction with blood in vitro.
- Record ID
- CUT439179755a9c4f62859a70c998a9a6e8
- Publication type
- Publication categories
- ; ;
- Author
- Pages
- 95-110
- Other elements of collation
- il.; Bibliografia (liczba pozycji) - 35; Oznaczenie streszczenia - Abstr.
- Book
- Pogrebnjak Alexander D., Alexander D. Pogrebnjak Pogorielov Maksym, Maksym Pogorielov Viter Roman Roman Viter (eds.): Nanomaterials in biomedical application and biosensors (NAP-2019), Springer Proceedings in Physics, no. 244, 2020, Singapore, Springer, Springer, ISBN 978-981-15-3996-1 (eBook)
- Keywords in English
- chitosan, hemostatic sponges
- DOI
- DOI:10.1007/978-981-15-3996-1_10 Opening in a new tab
- URL
- https://link.springer.com/book/10.1007/978-981-15-3996-1 Opening in a new tab
- Related project
- Synteza i badanie właściwości nowych termoplastycznych pochodnych chitozanu o kontrolowanej biodegradowalności. . Project leader at PK: , ,
Projects financed by NSC [Projekty finansowane przez NCN] - Language
- eng (en) English
- Score (nominal)
- 20
- Additional fields
- Indeksowana w: Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT439179755a9c4f62859a70c998a9a6e8/
- URN
urn:pkr-prod:CUT439179755a9c4f62859a70c998a9a6e8
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.