Hemostatic performance and biocompatibility of chitosan-based agents in experimental parenchymal bleeding
Authors:
- V. Deineka,
- J. Radwan-Pragłowska,
- L. Janus,
- M. Piątkowski
Abstract
The uncontrolled parenchymatic bleeding is still a cause of serious complications in surgery and require new effective hemostatic materials. In recent years, numerous chitosan-based materials have been intensively studied for parenchymatic bleeding control but still require to increased safety and effectiveness. The current research is devoted to new hemostatic materials made of natural polymer (chitosan) developed using electrospinning and microwave-assisted methods. Hemostatic performance, biocompatibility, degradation, and in-vivo effectiveness were studied to assess functional properties of new materials. Chitosan-based agents demonstrated considerable hemostatic performance, moderate biodegradation pace and high biocompatibility in vitro. Using the electrospinning-made chitosan-copolymer significantly improved in vivo biocompatibility and degradation of Chitosan-based agents that provides opportunities for its implementation for visceral bleeding management. Chitosan aerogel could be effectively applied in hemostatic patch development due to high antibacterial activity but it is not recommended for visceral application due to moderate inflammatory effect and slow degradation.
- Record ID
- CUTe47f270a22544044a981a86d95edee54
- Publication categories
- ;
- Author
- Journal series
- Materials Science and Engineering. C, ISSN 0928-4931, e-ISSN 1873-0191, Irregular
- Issue year
- 2021
- Vol
- 120
- Pages
- [1-12]
- Article number
- 111740
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 11-12; Bibliografia (liczba pozycji) - 46; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 120
- Keywords in English
- chitosan, biodegradation, hemostasis, electrospinning, aerogel, biocompatibility
- DOI
- DOI:10.1016/j.msec.2020.111740 Opening in a new tab
- URL
- https://www.sciencedirect.com/science/article/pii/S0928493120336596 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 140
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTe47f270a22544044a981a86d95edee54/
- URN
urn:pkr-prod:CUTe47f270a22544044a981a86d95edee54
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.