Impact of the type of crosslinking agents on the properties of modified sodium alginate/poly(vinyl alcohol) hydrogels
Authors:
- Katarzyna Bialik-Wąs,
- Ewelina Królicka,
- Dagmara Malina
Abstract
Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.
- Record ID
- CUTcf6a08616b6b409686fde670cdb8a35d
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2021
- Vol
- 2
- No
- 8
- Pages
- [1-17]
- Article number
- 2381
- Other elements of collation
- fot.; schem.; tab.; wykr.; Bibliografia (na s.) - 15-17; Bibliografia (liczba pozycji) - 58; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 2, Iss. 8
- Substantive notes
- Section: Materials Chemistry
- Keywords in English
- SA/PVA hydrogels, Echinacea purpurea, release profile, various crosslinking agents
- DOI
- DOI:10.3390/molecules26082381 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/26/8/2381#metrics Opening in a new tab
- Related project
- Synteza i zastosowanie związków bioaktywnych. . Project leader at PK: , ,
Działalność statutowa - Language
- eng (en) English
- License
- Score (nominal)
- 140
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTcf6a08616b6b409686fde670cdb8a35d/
- URN
urn:pkr-prod:CUTcf6a08616b6b409686fde670cdb8a35d
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.