Emulsions as vehicles for the controlled release of astaxanthin in topical application
Authors:
- Michał Dymek,
- Elżbieta Sikora
Abstract
In the work, the antioxidant activity of astaxanthin (AST) and the influence of the base formulation on the kinetics of AST release were studied. Three stable O/W ASTloaded emulsions, differing in the internal phase droplet size (12.7 μm (E1), 3.8 μm (E2), 3.2 μm (E3)) and a nanoemulsion (0.13 μm, NE) were prepared. The results confirmed very strong antioxidant activity of AST. The emulsion internal phase droplet size did not significantly affect the AST release. The amount of released AST was respectively: 13.60% (E1), 11.42% (E2), 9.45% (E3), 9.71% (NE). The best fit to experimental data was obtained using the Higuchi model for emulsions and the Korsmeyer-Peppas model for NE. The results show that the AST release process is limited by the diffusion through carriers and the prepared O/W emulsions can be used as vehicles for the controlled delivery of AST to the skin.
- Record ID
- CUTafb32c286b1d42fa97a1a92e14075929
- Publication categories
- ; ;
- Author
- Pages
- 35-41
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 40-41; Bibliografia (liczba pozycji) - 36; Oznaczenie streszczenia - Abstr.
- Substantive notes
- Rozszerzony abstr. ref. zamieszczono również na s. 177
- Book
- EYEC monograph : 9th European Young Engineers Conference, 2021, Warsaw, Politechnika Warszawska, Faculty of Chemical and Process Engineering. Warsaw University of Technology, ISBN 978-83-936575-9-9
- Keywords in English
- astaxanthin, release kinetics, skin delivery systems, emulsions, antioxidant activity
- URL
- https://www.eyec.ichip.pw.edu.pl/?page_id=2995 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 20
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTafb32c286b1d42fa97a1a92e14075929/
- URN
urn:pkr-prod:CUTafb32c286b1d42fa97a1a92e14075929
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