Synthesis and characterization of polymer-based coatings modified with bioactive ceramic and bovine serum albumin
Authors:
- Wioletta Florkiewicz,
- Dagmara Słota,
- Angelika Placek,
- Klaudia Pluta,
- Bożena Tyliszczak,
- Timothy E. L. Douglas,
- Agnieszka Sobczak-Kupiec
Abstract
This study involves the synthesis of hydroxyapatite and describes the preparation and characterization of polymer coatings based on poly(ethylene glycol) diacrylate and poly(ethylene glycol) and modified with bovine serum albumin and hydroxyapatite. Hydroxyapatite was obtained by wet chemical synthesis and characterized by X-ray diffraction and FTIR spectroscopy, and its Ca/P molar ratio was determined (1.69 ± 0.08). The ceramic and bovine serum albumin were used in the preparation of composite materials with the polymeric matrix. The chemical composition of coatings was characterized with FTIR spectroscopy, and their morphology was recorded with SEM imaging. Moreover, the measurements of surface roughness parameters and stereometric research were performed. The prepared coatings were subjected to in vitro studies in simulated body fluid and artificial saliva. Changes in chemical composition and morphology after immersion were examined with FTIR spectroscopy and SEM imaging. Based on the conducted research, it can be stated that applied modifiers promote the biomineralization process. The roughness analysis confirmed prepared materials were characterized by the micrometer-scale topography. The materials morphology and roughness, and the morphology of the newly formed apatite deposit, were dependent on the type of the used modifier, and the artificial fluid used in in vitro studies.
- Record ID
- CUTa3b5adc5f22847459fc9ddd3da1b75e8
- Publication categories
- ;
- Author
- Journal series
- Journal of Functional Biomaterials, ISSN , e-ISSN 2079-4983, Monthly
- Issue year
- 2021
- Vol
- 12
- No
- 2
- Pages
- [1-16]
- Article number
- 21
- Other elements of collation
- fot.; rys.; tab.; wykr.; Bibliografia (na s.) - 14-16; Bibliografia (liczba pozycji) - 43; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 12, Iss. 2, Spec. Iss.
- Substantive notes
- Tyt. Spec. Iss.: Bioinspired Materials for Medical and Biotechnological Applications
- Keywords in English
- hydroxyapatite, bovine serum albumin, polyethylene glycol, composite coatings, biomineralization
- DOI
- DOI:10.3390/jfb12020021 Opening in a new tab
- URL
- https://www.mdpi.com/2079-4983/12/2/21 Opening in a new tab
- Related project
- Opracowanie składu powłok kompozytowych modyfikowanych nanocząstkami metalicznymi zawierających fosforany wapnia pochodzenia naturalnego i syntetycznego. . Project leader at PK: , ,
Projects financed by NSC [Projekty finansowane przez NCN] - Language
- eng (en) English
- License
- Score (nominal)
- 100
- Publication indicators
- = 13
- Additional fields
- Indeksowana w: Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTa3b5adc5f22847459fc9ddd3da1b75e8/
- URN
urn:pkr-prod:CUTa3b5adc5f22847459fc9ddd3da1b75e8
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.