Development of stimuli-responsive chitosan/ZnO NPs transdermal systems for controlled cannabidiol delivery
Authors:
- Julia Radwan-Pragłowska,
- Łukasz Janus,
- Marek Piątkowski,
- Aleksandra Sierakowska,
- Ernest Szajna,
- Dalibor Matýsek,
- Dariusz Bogdał
Abstract
One of the most common neurological diseases is epilepsy, which not only negatively affects the quality of people’s life but also may lead to life-threatening situations when its symptoms such as seizures cannot be controlled medically. A very serious problem to be overcame is the untreatable form of this disease, which cannot be cured by any currently available medicines. Cannabidiol, which is a natural product obtained from Cannabis Sativa, brings a new hope to people suffering from drug-resistant epilepsy. However, the hydrophobic character of this compound significantly lowers its clinical efficiency. One of the promising methods of this substance bioactivity increase is delivery through the skin tissue. In this article, a new type of advanced transdermal systems based on chitosan and ZnO nanoparticles (NPs) has been developed according to Sustained Development principles. The chemical modification of the biopolymer confirmed by FT-IR method resulted in the preparation of the material with great swelling abilities and appropriate water vapor permeability. Obtained nanoparticles were investigated over their crystalline structure and morphology and their positive impact on drug loading capacity and cannabidiol controlled release was proved. The novel biomaterials were confirmed to have conductive properties and not be cytotoxic to L929 mouse fibroblasts.
- Record ID
- CUT2b6de40ca8d2418b95b1934843c245bb
- Publication categories
- ;
- Author
- Journal series
- Polymers, ISSN , e-ISSN 2073-4360, Biweekly
- Issue year
- 2021
- Vol
- 13
- No
- 2
- Pages
- [1-19]
- Article number
- 211
- Other elements of collation
- fot.; rys.; tab.; wykr.; Bibliografia (na s.) - 17-19; Bibliografia (liczba pozycji) - 43; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 13, Iss. 2, Spec. Iss.
- Substantive notes
- Special Issue: Polymeric Carrier Systems Enabling Transdermal Drug Delivery
- Keywords in English
- chitosan, drug delivery, cannabidiol
- DOI
- DOI:10.3390/polym13020211 Opening in a new tab
- URL
- https://www.mdpi.com/2073-4360/13/2/211 Opening in a new tab
- Related project
- Synteza i badanie właściwości bioaktywnych nanokompozytów chitozanowych o właściwościach półprzewodzących przetwarzanych technologią druku 3D. . Project leader at PK: , ,
Projects financed by NSC [Projekty finansowane przez NCN] - Language
- eng (en) English
- License
- Score (nominal)
- 100
- Publication indicators
- = 12
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT2b6de40ca8d2418b95b1934843c245bb/
- URN
urn:pkr-prod:CUT2b6de40ca8d2418b95b1934843c245bb
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.