Selective cytotoxicity of complexes with N,N,N-Donor dipodal ligand in tumor cells
Authors:
- Małgorzata Tyszka-Czochara,
- Anna Adach,
- Tomasz Grabowski,
- Paweł Konieczny,
- Paweł Pasko,
- Joanna Ortyl,
- Tomasz Świergosz,
- Marcin Majka
Abstract
The present article demonstrates selective cytotoxicity against cancer cells of the complexes [Co(LD)2]I2∙CH3OH (1), [CoLD(NCS)2] (2) and [VOLD(NCS)2]∙C6H5CH3 (3) containing the dipodal tridentate ligand LD = N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine), formed in situ. All tested complexes expressed greater anticancer activities and were less toxic towards noncancerous cells than cisplatin. Cobalt complexes (1 and 2) combined high cytotoxicity with selectivity towards cancer cells and caused massive tumour cell death. The vanadium complex (3) induced apoptosis specifically in cancer cells and targeted proteins, controlling their invasive and metastatic properties. The presented experimental data and computational prediction of drug ability of coordination compounds may be helpful for designing novel and less toxic metal-based anticancer species with high specificities towards tumour cells.
- Record ID
- CUT964f77288d0b44a09f0b8d03fdb525d7
- Publication categories
- ;
- Author
- Journal series
- International Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067, Biweekly
- Issue year
- 2021
- Vol
- 22
- No
- 4
- Pages
- 1-16
- Article number
- 1802
- Other elements of collation
- schem.; tab.; wykr.; Bibliografia (na s.) - 13-16; Bibliografia (liczba pozycji) - 54; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 22, Iss. 4
- Keywords in English
- cytotoxicity, selectivity, cancer, VO2+, Co2+ complexes, N,N-bis(3,5-dimethylpyrazolyl-1-methyl)amine
- DOI
- DOI:10.3390/ijms22041802 Opening in a new tab
- URL
- https://www.mdpi.com/1422-0067/22/4/1802/htm Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT964f77288d0b44a09f0b8d03fdb525d7/
- URN
urn:pkr-prod:CUT964f77288d0b44a09f0b8d03fdb525d7
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.