Cracking the chloroquine conundrum: the application of defective UiO-66 metal–organic framework materials to prevent the onset of heart defects-in vivo and in vitro
Authors:
- Przemysław J. Jodłowski,
- Grzegorz Kurowski,
- Łukasz Kuterasiński,
- Maciej Sitarz,
- Piotr Jeleń,
- Jolanta Jaśkowska,
- Andrzej Kołodziej,
- Anna Pajdak,
- Zbigniew Majka,
- Anna Boguszewska-Czubara
Abstract
In this study, we present a modulated synthesisnanocrystalline defective UiO-66 metal−organic framework as apotential chloroquine diphosphate (CQ) delivery system. Increas-ing the concentration of hydrochloric acid during the modulatedsynthesis resulted in a considerable increase of pore volume, whichenhanced the CQ loading in CQ@UiO-66 composites. Drugrelease tests for CQ@UiO-66 composites have confirmedprolonged CQ release in comparison with pure CQ. In vivo testson aDanio reiromodel organism have revealed that CQ releasedfrom CQ@UiO-66 25% showed lower toxicity and fewercardiotoxic effects manifested by cardiac malformations andarrhythmia in comparison to analogous doses of CQ. Cytotoxicitytests proved that the CQ loaded on the defective UiO-66 cargo resulted in increased viability of cardiac cells (H9C2) as compared toincubation with pure CQ. The experimental results presented here may be a step forward in the context of reducing the cardiotoxicity CQ.
- Record ID
- CUT2e4d50fa80d14baaaa06ab748403fad5
- Publication categories
- ;
- Author
- Journal series
- ACS Applied Materials & Interfaces, ISSN 1944-8244, e-ISSN 1944-8252
- Issue year
- 2021
- Vol
- 13
- No
- 1
- Pages
- 312-323
- Other elements of collation
- fot.; rys.; tab.; wykr.; Bibliografia (na s.) - 322-323; Bibliografia (liczba pozycji) - 56; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 13, Iss. 1
- Keywords in English
- chloroquine, drug delivery, metal-organic frameworks, SARS-CoV-2, UiO-66
- DOI
- DOI:10.1021/acsami.0c21508 Opening in a new tab
- URL
- https://pubs.acs.org/doi/full/10.1021/acsami.0c21508 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 200
- Publication indicators
- = 27
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT2e4d50fa80d14baaaa06ab748403fad5/
- URN
urn:pkr-prod:CUT2e4d50fa80d14baaaa06ab748403fad5
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.