The responses of bioactive betanin pigment and its derivatives from a red beetroot (Beta vulgaris L.) betalain-rich extract to hypochlorous acid
Authors:
- Karolina Starzak,
- Katarzyna Sutor,
- Tomasz Świergosz,
- Boris Nemzer,
- Zbigniew Pietrzkowski,
- Łukasz Popenda,
- Shi-Rong Liu,
- Shu-Pao Wu,
- Sławomir Wybraniec
Abstract
Neutrophils produce hypochlorous acid (HOCl) as well as other reactive oxygen species as part of a natural innate immune response in the human body; however, excessive levels of HOCl can ultimately be detrimental to health. Recent reports suggest that betacyanin plant pigments can act as potent scavengers of inflammatory factors and are notably effective against HOCl. Comparison of the in vitro anti-hypochlorite activities of a novel betalain-rich red beetroot (Beta vulgaris L.) extract with its pure betalainic pigments revealed that the extract had the highest anti-hypochlorite activity, far exceeding the activity of all of the betalainic derivatives and selected reference antioxidants. This suggests that it may be an important food-based candidate for management of inflammatory conditions induced by excessive HOCl production. Among all pigments studied, betanidin exhibited the highest activity across the pH range.
- Record ID
- CUTa62c56f42097457dac8344dfc2fa7092
- Publication categories
- ;
- Author
- Journal series
- International Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067, Biweekly
- Issue year
- 2021
- Vol
- 22
- No
- 3
- Pages
- [1-18]
- Article number
- 1155
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 17-18; Bibliografia (liczba pozycji) - 41; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 22, Iss. 3, Spec. Iss.
- Substantive notes
- Special Issue: Biological Properties of Medicinal Plants
- Keywords in English
- betacyanins, betalain rich extract, inflammation, hypochlorite scavenging
- DOI
- DOI:10.3390/ijms22031155 Opening in a new tab
- URL
- https://www.mdpi.com/1422-0067/22/3/1155 Opening in a new tab
- Related project
- Badania mechanizmu utleniania pigmentów betacyjanin. . Project leader at PK: , ,
Projects financed by NSC [Projekty finansowane przez NCN] - Language
- eng (en) English
- License
- Score (nominal)
- 140
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTa62c56f42097457dac8344dfc2fa7092/
- URN
urn:pkr-prod:CUTa62c56f42097457dac8344dfc2fa7092
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.