Preparation and characterization of bio-hybrid hydrogel materials
Authors:
- Dagmara Malina,
- Ewelina Królicka,
- Katarzyna Bialik-Wąs,
- Klaudia Pluta
Abstract
In recent decades, research has focused on the development of modern hydrogel dressings due to their open porous structure, moisture retention and good mechanical strength, which ensures an optimal environment for cell migration and proliferation. Active hydrogel dressings, currently available on the market, are not endowed with additional medicinal substan-ces. In this work the authors attempted to introduce a carrier-drug system into the hydrogel matrix to improve the wound healing process and the tissue recovery. The main goal of the research was to obtain the bio-hybrid sodium alginate/poly(vinyl alcohol)/Aloe vera (SA/PVA/AV)-based hydrogel matrices modified with the thermosensitive polymeric carrier – the active substance (hydrocortisone) system. First, thermosens-itive polymeric nanocarriers were obtained, then the encapsulation was conducted, using varied amounts of hydrocortisone (25 and 50 mg) to maintain the sta-bility of the resulting emulsions. The last stage was preparing the bio-hybrid hydrogel matrices by the che-mical cross-linking method. The non-invasive dynamic light scattering (DLS) technique was employed for the analysis of the average particle size of the polymeric carriers and the carrier-drug systems. Moreover, the studies also determined the swelling behaviour and the gel fraction of the obtained bio-hybrid hydrogel matrices modified with carrier-drug systems by the infrared spectroscopy (FT-IR). The presented research results constitute a good experimental basis for further modifications, the final effect of which is assumed to be a modern bio-hybrid 3rd generation dressing.
- Record ID
- CUT3d7dae8428e44aa59a3266cfc33e7d7d
- Publication categories
- ;
- Author
- Journal series
- Engineering of Biomaterials / Inżynieria Biomateriałów, ISSN 1429-7248
- Issue year
- 2020
- Vol
- 23
- No
- 155
- Pages
- 12-16
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 16; Bibliografia (liczba pozycji) - 26; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 23, No. 155
- Keywords in English
- hydrogel matrix, drug delivery system, carrier-drug system, synthesis, hydrocortisone
- DOI
- DOI:10.34821/eng.biomat.155.2020.12-16 Opening in a new tab
- URL
- http://www.biomaterials.pl/Preparation-and-characterization-of-bio-hybrid-hydrogel-materials,130575,0,2.html Opening in a new tab
- Related project
- Opracowanie metody otrzymywania bio-hybrydowych materiałów hydrożelowych inkorporowanych systemem nanonośnik-lek jako wielokompartmentowych opatrunków umożliwiających leczenie Psoriasis. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- License
- Score (nominal)
- 20
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT3d7dae8428e44aa59a3266cfc33e7d7d/
- URN
urn:pkr-prod:CUT3d7dae8428e44aa59a3266cfc33e7d7d
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.