Preparation of titanium oxide-based nanoparticles modified with D-(+)-mannose and investigation of their properties as a potential drug carrier
Authors:
- Jolanta Pulit-Prociak,
- Anita Staroń,
- Olga Długosz,
- Klaudia Kluz,
- Marcin Banach
Abstract
Titanium oxide nanoparticles modified with D-(?)-mannose were obtained. In the process of their formation, they were conjugated with an active substance (tadalafil). The physicochemical properties of the obtained products were assessed, and the size and electrokinetic potential were determined using a dynamic light scattering technique. X-ray diffractometry was applied in order to define the crystalline properties, and Fourier-transform infrared spectroscopy was used to confirm the formation of the desired products. It was possible to obtain TiO2 coated with D-(?)-mannose. The average size of nanoparticles was between 230 and 268 nm. The release of the active substance from the product over a time period of three hours was assessed against the reference material, which was not modified by D-(?)-mannose. The results indicate that covering titanium oxide nanoparticles with the modifying substance favours a slower rate of release for the active substance, which is the desired effect from a pharmacological point of view. The releasing of active substance from modified products was even 68% slower than that from the reference product. These modified titanium oxides are promising materials that may have found an application as drug carriers.
- Record ID
- CUT2f5e503aa76445afae70683b13a24865
- Publication categories
- ;
- Author
- Journal series
- Journal of Cluster Science, ISSN 1040-7278, e-ISSN 1572-8862
- Issue year
- 2021
- Vol
- 32
- No
- 5
- Pages
- 1241-1252
- Other elements of collation
- fot.; schem.; tab.; wykr.; Bibliografia (na s.) - 1251-1252; Bibliografia (liczba pozycji) - 46; Oznaczenie streszczenia - Abstr.; Data udostępnienia on-line - 2020-09-19; Numeracja w czasopiśmie - Vol. 32, Iss. 5
- Keywords in English
- medicine delivery systems, aldohexosis, tadalafil, active substance releasing
- DOI
- DOI:10.1007/s10876-020-01889-2 Opening in a new tab
- URL
- https://link.springer.com/article/10.1007/s10876-020-01889-2#article-info Opening in a new tab
- Related project
- Opracowanie sposobu wytwarzania nietoksycznych nośników substancji czynnych na bazie nanomateriałów. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- License
- Score (nominal)
- 70
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT2f5e503aa76445afae70683b13a24865/
- URN
urn:pkr-prod:CUT2f5e503aa76445afae70683b13a24865
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.