10-Methylthiocolchicine complexes with lithium, sodium, potassium, rubidium and cesium metal cations salts – Cytotoxic, semi-empirical and molecular modelling studies
Authors:
- Joanna Kurek,
- Patrycja Kwaśniewska-Sip,
- Krzysztof Myszkowski,
- Tomasz Pospieszny,
- Grzegorz Cofta,
- Marek Murias,
- Rafał Kurczab,
- Paweł Śliwa
Abstract
Thiocolchicine (10-methylthiocolchicine) is a semi-synthetic alkaloid with notable cytotoxic activity.Complexes of 10-methylthiocolchicine with Li+,Na+,K+,Rb+and Cs+monovalent cations of perchloratesand iodides have been obtained and characterized by spectroscopic methods, semi-empirical studies andmolecular modelling. An explanation of the chemical nature of complexes formed between this alkaloidand monovalent metal cations of perchlorate and iodide salts which are present in human daily life isimportant. Their activities as cytotoxic and antifungal agents were also tested against the SKOV-3 cancercell line and for eight selected microfungi species, respectively. Biological tests indicated no antifungalproperties for 10-methylthiocolchicine. Complexation of 10-methylthiocolchicine with monovalentmetal cations significantly improved the anticancer potency (~IC50= 4 nM) against the SKOV-3 cancer cellline.
- Record ID
- CUTaa810ed3840d46e29fa75795ec750394
- Publication categories
- ;
- Author
- Journal series
- Polyhedron, ISSN 0277-5387
- Issue year
- 2020
- Vol
- 190
- Pages
- [1-11]
- Article number
- 114791
- Other elements of collation
- schem.; tab.; wykr.; Bibliografia (na s.) - 11; Bibliografia (liczba pozycji) - 29; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 190
- Keywords in English
- complexes of 10-methylthiocolchicine, cytotoxic activity, fungicidal activity, PM5 calculation, molecular modelling
- DOI
- DOI:10.1016/j.poly.2020.114791 Opening in a new tab
- URL
- https://www.sciencedirect.com/science/article/abs/pii/S0277538720304484 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 100
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTaa810ed3840d46e29fa75795ec750394/
- URN
urn:pkr-prod:CUTaa810ed3840d46e29fa75795ec750394
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