Physicochemical investigations of chitosan-based hydrogels containing aloe vera designed for biomedical use
Authors:
- Anna Drabczyk,
- Sonia Kudłacik-Kramarczyk,
- Magdalena Głąb,
- Magdalena Kędzierska,
- Anna Jaromin,
- Dariusz Mierzwiński,
- Bożena Tyliszczak
Abstract
In this work, synthesis and investigations on chitosan-based hydrogels modified with Aloe vera juice are presented. These materials were synthesized by UV radiation. Investigations involved analysis of chemical structure by FTIR spectroscopy, sorption properties in physiological liquids, strength properties by texture analyzer, surface topography by Atomic Force Microscopy (AFM technique), and in vitro cytotoxicity by MTT test using L929 murine fibroblasts. Particular attention was focused both on determining the impact of the amount and the molecular weight of the crosslinker used for the synthesis as well as on the introduced additive on the properties of hydrogels. It was proven that modified hydrogels exhibited higher swelling ability. Introduced additive affected the tensile strength of hydrogels—modified materials showed 23% higher elongation. The greater amount of the crosslinker used in the synthesis, the more compact the structure, leading to the lower elasticity and lower sorption of hydrogels was reported. Above 95%, murine fibroblasts remained viable after 24 h incubation with hydrogels. It indicates that tested materials did not exhibit cytotoxicity toward these lines. Additionally, materials with Aloe vera juice were characterized by lower surface roughness. Conducted investigations allowed us to state that such modified hydrogels may be considered as useful for biomedical purposes.
- Record ID
- CUT6d69a1e2ec2644f7a007dac7e070b255
- Publication categories
- ;
- Author
- Journal series
- Materials, ISSN , e-ISSN 1996-1944, Biweekly
- Issue year
- 2020
- Vol
- 13
- No
- 14
- Pages
- [1-19]
- Article number
- 3073
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 17-19; Bibliografia (liczba pozycji) - 48; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 13, Iss. 14, Spec. Iss.
- Substantive notes
- Tyt. spec. iss.: Advanced Polymeric Biomaterials: Preparation, characterization and applications
- Keywords in English
- hydrogels, chitosan, aloe vera, tensile strength, MTT reduction assay, cytotoxicity, surface morphology, composite polymers
- DOI
- DOI:10.3390/ma13143073 Opening in a new tab
- URL
- https://www.mdpi.com/1996-1944/13/14/3073/htm Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Publication indicators
- = 65
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT6d69a1e2ec2644f7a007dac7e070b255/
- URN
urn:pkr-prod:CUT6d69a1e2ec2644f7a007dac7e070b255
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.