Grape cane extracts as multifunctional rejuvenating cosmetic ingredient: evaluation of sirtuin activity, tyrosinase inhibition and bioavailability potential
Authors:
- Magdalena Anna Malinowska,
- Kévin Billet,
- Samantha Drouet,
- Thibaut Munsch,
- Marianne Unlubayir,
- Duangjai Tungmunnithum,
- Nathalie Giglioli-Guivarc’h,
- Christophe Hano,
- Arnaud Lanoue
Abstract
Grape canes are waste biomass of viticulture containing bioactive polyphenols valuable in cosmetics. Whereas several studies reported the cosmetic activities of E-resveratrol, only few described the potential of E-ε-viniferin, the second major constituent of grape cane extracts (GCE), and none of them investigated GCE as a natural blend of polyphenols for cosmetic applications. In this study, we considered the potential of GCE from polyphenol-rich grape varieties as multifunctional cosmetic ingredients. HPLC analysis was performed to quantify major polyphenols in GCE i.e., catechin, epicatechin, E-resveratrol, E-piceatannol, ampelopsin A, E-ε-viniferin, hopeaphenol, isohopeaphenol, E-miyabenol C and E-vitisin B from selected cultivars. Skin whitening potential through tyrosinase inhibition assay and the activation capacity of cell longevity protein (SIRT1) of GCE were compared to pure E-resveratrol and E-ε-viniferin. Drug-likeness of GCE polyphenols were calculated, allowing the prediction of skin permeability and bioavailability. Finally, the present data enabled the consideration of GCE frompolyphenol-rich varieties asmultifunctional cosmetic ingredients in accordance with green chemistry practices.
- Record ID
- CUTc4a4cd71010646078987864bcf05eaee
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2020
- Vol
- 25
- No
- 9
- Pages
- [1-16]
- Article number
- 2203
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 14-16; Bibliografia (liczba pozycji) - 47; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 25, Iss. 9, Spec. Iss.
- Substantive notes
- Special Issue: Biological Activities of Plant Secondary Metabolites
- Keywords in English
- grape cane extracts, natural ingredients, polyphenols, E-resveratrol, E-ε-viniferin, sirtuin activation, tyrosinase inhibition, drug-likeness
- DOI
- DOI:10.3390/molecules25092203 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/25/9/2203 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTc4a4cd71010646078987864bcf05eaee/
- URN
urn:pkr-prod:CUTc4a4cd71010646078987864bcf05eaee
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