Measurement methodology toward determination of structure-property relationships in acrylic hydrogels with starch and nanogold designed for biomedical applications
Authors:
- A. Drabczyk,
- S. Kudłacik-Kramarczyk,
- B. Tyliszczak,
- K. Rudnicka,
- M. Urbaniak,
- S. Michlewska,
- J. B. Królczyk,
- P. Gajda,
- K. Pielichowski
Abstract
This work describes measurement methodology on acrylic acid-based hydrogels with nanogold and starch, including evaluation of pro-inflammatory activity and cytotoxicity by MTT reduction assay, swelling capacity, tensile strength using Brookfield texture analyzer, surface morphology by scanning electron microscopy, structure by FT-IR spectroscopy, crystallinity by X-ray diffraction and hydrogel behaviour in simulated body fluids. The modified polymers exhibited approx. 75% lower deformation than unmodified polymer. Hydrogels showed buffering properties in simulated body fluids. Hydrogels containing 5–10% starch solution did not exhibit cytotoxicity. Cells exposed to unmodified hydrogel and to hydrogels containing 5% and 10% starch solutions were characterized by the desired morphology. Importantly, hydrogel nanocomposites have not showed pro-inflammatory activity. It was proved that highly developed specific surface area of modified hydrogels affected their sorption properties. Nanogold present in nanocomposites did not affect directly their physicochemical properties but, due to its features, antibacterial activity of so modified materials could be enhanced.
- Record ID
- CUT82f6d4a4c3e7441f81a0294b197b3349
- Publication categories
- ;
- Author
- Journal series
- Measurement, ISSN 0263-2241, e-ISSN 1873-412X
- Issue year
- 2020
- Vol
- 156
- Pages
- [1-12]
- Article number
- 107608
- Other elements of collation
- il. (gł. kolor.); Bibliografia (na s.) - 11-12; Bibliografia (liczba pozycji) - 51; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 156
- Keywords in English
- acrylic hydrogels, gold nanoparticles, measurement methodology, pro-inflammatory activity, starch, tensile strength
- DOI
- DOI:10.1016/j.measurement.2020.107608 Opening in a new tab
- URL
- https://www.sciencedirect.com/science/article/pii/S0263224120301457 Opening in a new tab
- Related project
- Międzynarodowa wymiana stypendialna doktorantów i kadry akademickiej. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 200
- Publication indicators
- = 11
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT82f6d4a4c3e7441f81a0294b197b3349/
- URN
urn:pkr-prod:CUT82f6d4a4c3e7441f81a0294b197b3349
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.