In vitro biosafety of pro-ecological chitosan-based hydrogels modified with natural substances
Authors:
- Bożena Tyliszczak,
- Anna Drabczyk,
- Sonia Kudłacik-Kramarczyk,
- Karolina Rudnicka,
- Justyna Gatkowska,
- Agnieszka Sobczak-Kupiec,
- Josef Jampílek
Abstract
Hydrogels belong to the group of materials with growing interest on the market of polymers. In this article, hydrogels based on Beetosan were obtained using ultraviolet (UV) radiation. Main component of hydrogel matrix—Beetosan—is chitosan obtained from naturally died honeybees. Such hydrogels were modified with active substances, that is, caffeine, bee pollen, Salvia officinalis (sage), and Aloe vera juice. Next, the analysis of cytotoxicity of hydrogels in relation to murine fibroblasts by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide and neutral red uptake assays were conducted. Furthermore, surface morphology, tensile strength, geometry, and roughness of hydrogels were characterized. Hydrogels did not show cytotoxicity to recommended L929 murine fibroblasts. These polymers did not affect adversely the growth and viability of these cells. Moreover, Beetosan hydrogels were characterized by flexibility as well as by diversified surface morphology that could indicate their high absorbency. Therefore these materials may be considered as useful for biomedical purposes with special emphasis on application as modern wound dressings that not only absorb wound exudate but also contain natural substances with therapeutic properties that is beneficial from the point of view of wound healing process.
- Record ID
- CUT9e9dc7490a2e484397bc3d19ea73c60d
- Publication categories
- ;
- Author
- Journal series
- Journal of Biomedical Materials Research Part A, ISSN 1549-3296, e-ISSN 1552-4965, [1552-4965]
- Issue year
- 2019
- Vol
- 107
- No
- 11
- Pages
- 2501-2511
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 2510-2511; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 107, Iss. 11
- Keywords in English
- AFM analysis, chitosan hydrogels, cytotoxicity assays, tensile strength, wound dressings
- DOI
- DOI:10.1002/jbm.a.36756 Opening in a new tab
- URL
- https://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.36756 Opening in a new tab
- Related project
- Zastosowanie Beetosanu do otrzymywania nowoczesnych biomedycznych matryc hydrożelowych. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- Score (nominal)
- 100
- Publication indicators
- = 25
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT9e9dc7490a2e484397bc3d19ea73c60d/
- URN
urn:pkr-prod:CUT9e9dc7490a2e484397bc3d19ea73c60d
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.