Antifungal, anticancer and docking studies of colchiceine complexes with monovalent metal cation salts
Authors:
- Joanna Kurek,
- Patrycja Kwaśniewska‐Sip,
- Krzysztof Myszkowski,
- Grzegorz Cofta,
- Piotr Barczyński,
- Marek Murias,
- Rafał Kurczab,
- Paweł Śliwa,
- Piotr Przybylski
Abstract
Complexes of colchiceine with monovalent cation perchlorates and iodides have been obtained and characterized by spectroscopic methods. DFT and spectroscopic studies reveal that the dihedral angle ω1‐1a‐12‐12a, crucial for colchicine biological mechanism of action i.e. binding to tubulins depends on the diameter of the complexed metal cation. Biological tests indicated no antifungal properties of colchicine (it was active only towards A.pullulans), in contrast to its derivative – (colchiceine). Complexation of colchiceine with metal cations improved significantly the antifungal potency, even below MIC <1 μg/mL. The colchiceine complexes were more potent than colchiceine and some of them were even more potent than the fungicidal standard IPBC. The highest potency of colchiceine complexes was noted against A. pullulans (MIC = 0.5 μg/mL). In contrast to the findings concerning antifungal potency, the anticancer studies showed complexes of colchicine more active (~IC50 = 2 nM) than those of colchiceine (~IC50 = 6 μM). MDA‐MB‐231 breast cancer cell lines and human lung fibroblasts CCD39Lu were also tested.
- Record ID
- CUTd2fc3122a2da46fca22a9954e73c10f5
- Publication categories
- ;
- Author
- Journal series
- Chemical Biology & Drug Design, ISSN 1747-0277, e-ISSN 1747-0285
- Issue year
- 2019
- Vol
- 94
- No
- 5
- Pages
- 1930-1943
- Other elements of collation
- fot.; rys.; tab.; wykr.; Bibliografia (na s.) - 1941-1943; Bibliografia (liczba pozycji) - [43]; Oznaczenie streszczenia - Abstr.; Data udostępnienia on-line - 2019-07-01; Numeracja w czasopiśmie - Vol. 94, Iss. 5
- Keywords in English
- tropolone alkaloids, colchiceine, complexes with metal iodides and perchlorates, fungistatic activity, cytotoxic activity
- DOI
- DOI:10.1111/cbdd.13583 Opening in a new tab
- URL
- https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13583 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 70
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTd2fc3122a2da46fca22a9954e73c10f5/
- URN
urn:pkr-prod:CUTd2fc3122a2da46fca22a9954e73c10f5
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.