3D scaffolds prepared from acylated chitosan applicable in skin regeneration – synthesis and characterization
Authors:
- Julia Radwan-Pragłowska,
- Marek Piątkowski,
- Łukasz Janus,
- Dariusz Bogdał,
- Dalibor Matysek,
- Vladimir Cablik
Abstract
Nowadays, burn wounds are one of the most emerging problems of medicine. Tissue engineering seems to be a promising solution since it enables new tissue formation on 3 D scaffolds. In this article, a novel strategy for N-acylated chitosan 3 D scaffolds obtainment method is presented. Biomaterials were synthesized according to Green Chemistry principles under microwave-assisted conditions using unsaturated fatty acid chlorides. Ready products were characterized over their physicochemical properties, morphology, mechanical, and biological properties. Performed analyses confirmed obtainment of N-acylated biomaterial with a very porous structure and enhanced durability. Prepared scaffolds were biodegradable and had a positive impact on mouse fibroblasts.
- Record ID
- CUTf91d9ef060ff4b49a01469711544205c
- Publication categories
- ;
- Author
- Journal series
- International Journal of Polymer Analysis and Characterization, ISSN 1023-666X, e-ISSN 1563-5341
- Issue year
- 2019
- Vol
- 24
- No
- 1
- Pages
- 75-86
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 86; Bibliografia (liczba pozycji) - 15; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 24, Iss. 1
- Keywords in English
- chitosan, biodegradable polymers, biomaterials, 3D scaffolds, microwave radiation, Green Chemistry
- DOI
- DOI:10.1080/1023666X.2018.1553348 Opening in a new tab
- URL
- https://www.tandfonline.com/doi/abs/10.1080/1023666X.2018.1553348?journalCode=gpac20 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 70
- Publication indicators
- = 5
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTf91d9ef060ff4b49a01469711544205c/
- URN
urn:pkr-prod:CUTf91d9ef060ff4b49a01469711544205c
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.