Microwave-assisted synthesis and characterization of antibacterial O-crosslinked chitosan hydrogels doped with TiO2 nanoparticles for skin regeneration
Authors:
- Julia Radwan-Pragłowska,
- Marek Piątkowski,
- Łukasz Janus,
- Dariusz Bogdał,
- Dalibor Matysek,
- Vladimir Čablik
Abstract
Tissue engineering provides alternative solutions to traditional transplantation. In this study a novel strategy of chitosan scaffolds obtainment based on selective O-crosslinking using Aspartic acid and the addition of TiO2 nanoparticles is presented. Prepared under microwave conditions biomaterials were of increased mechanical and thermal durability thanks to NPs presence comparing to pure chitosan. Moreover porous scaffolds maintained antimicrobial activity against S. Aureus and E. Coli. Biomaterials were susceptible to in vitro biodegradation and degradation. Hydrogels exhibited positive impact on proliferation activity of fibroblasts. Thus they may be applied as 3D scaffolds in tissue engineering focused on wound healing.
- Record ID
- CUT4f0770e2ef05469c9fb5309860fe1d28
- Publication categories
- ;
- Author
- Journal series
- International Journal of Polymeric Materials, ISSN 0091-4037, e-ISSN 1563-535X
- Issue year
- 2019
- Vol
- 68
- No
- 15
- Pages
- 881-890
- Other elements of collation
- rys.; wykr.; Bibliografia (na s.) - 890; Bibliografia (liczba pozycji) - 24; Oznaczenie streszczenia - Abstr.; Data udostępnienia on-line - 2018-10-10; Numeracja w czasopiśmie - Vol. 68, Iss. 15
- Keywords in English
- antibacterial materials, biocompatible polymers, biodegradable materials, cell culture, chitosan
- DOI
- DOI:10.1080/00914037.2018.1517351 Opening in a new tab
- URL
- https://www.tandfonline.com/doi/abs/10.1080/00914037.2018.1517351?journalCode=gpom20 Opening in a new tab
- Related project
- Synteza i badanie właściwości nowych termoplastycznych pochodnych chitozanu o kontrolowanej biodegradowalności. . Project leader at PK: , ,
Projects financed by NSC [Projekty finansowane przez NCN] - Language
- eng (en) English
- Score (nominal)
- 70
- Publication indicators
- = 9
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT4f0770e2ef05469c9fb5309860fe1d28/
- URN
urn:pkr-prod:CUT4f0770e2ef05469c9fb5309860fe1d28
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.