On the role of histomorphometric (stereological) microstructure parameters in the prediction of vertebrae compression strength
Authors:
- Leszek Wojnar,
- Aneta Gądek-Moszczak,
- Jacek Pietraszek
Abstract
The well-documented relation between bone mineral density (BMD) and bone compression strength constitutes the basis for osteoporosis diagnostics and the assessment of fracture risk. Simultaneously, this relation demonstrates a considerable scatter of results as bones of identical mineral density may have significantly different properties. The experimentally confirmed theorem that two materials or tissues of identical microstructure have identical properties leads to the evaluation of various quantitative stereological parameters (also referred to in biomedicine as histomorphology). These parameters, obtained from analysis of 2D or 3D images, have been used in numerous attempts to explain changes in bone strength. Although numerous correlation dependencies, often with high correlation coefficients, were evaluated, we do not know which parameters are worth evaluating, and there is no physical interpretation of these relations. An extended statistical analysis was accomplished on the basis of analysis of 3D images from 23 lumbar (L3) vertebrae scanned with micro-CT and the results of subsequent compression tests. A new parameter called SDF (structure destruction factor) was proposed in order to characterise the quality of 3D trabecular structures, and its significance was demonstrated. The final correlation function, which uses only three stereological parameters, made it possible to predict compression strength with considerable precision. The estimated values correlated very well with the apparent values (correlation coefficient r=0.96). Finally, the stereological parameters most suitable for characterisation of bone compression strength were chosen and a mechanism responsible for the changes in mechanical properties was proposed. The results obtained defined the necessary improvements in diagnostic techniques that would allow for more efficient quantitative microstructure evaluation and guidelines on how to improve treatment of patients with weakened bones.
- Record ID
- CUT6495f4448e004ccfae3727f267b5b515
- Publication categories
- ;
- Author
- Journal series
- Image Analysis and Stereology, ISSN 1580-3139
- Issue year
- 2019
- Vol
- 38
- No
- 1
- Pages
- 63-73
- Other elements of collation
- rys.; tab.; wykr.; Bibliografia (na s.) - 73; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 38, No. 1
- Keywords in English
- 3D image analysis, bone structure, compression strength, histomorphometry, osteoporosis, spine
- DOI
- DOI:105566/ias.2028 Opening in a new tab
- URL
- https://www.ias-iss.org/ojs/IAS/article/view/2028 Opening in a new tab
- Related project
- [N N518 423536] Opracowanie i optymalizacja metod diagnozowania ryzyka złamania w osteoporozie na podstawie analizy trójwymiarowych obrazów kości beleczkowej uzyskanych w warunkach in vivo. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 70
- Additional fields
- Indeksowana w: Web of Science
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT6495f4448e004ccfae3727f267b5b515/
- URN
urn:pkr-prod:CUT6495f4448e004ccfae3727f267b5b515
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.