Noncovalent interaction-assisted redox catalysis in reductive dehalogenation
Authors:
- Stefan S. Kurek,
- Piotr P. Romańczyk
Abstract
This chapter demonstrates how common are noncovalent interactions assisting catalytic reductive dehalogenation, including enzymatic reactions in reductive dehalogenases. Examples are given of halogen bonding, specific to the reactants in this process, facilitating it, but also hydrogen bonding, which may make the carbon–halogen bond more prone to cleavage or even provide a path for the electron transfer. Various types of noncovalent interactions locate the enzyme substrate in a position ideal for dehalogenation to proceed. Such systems are described, and also model systems, in which proximity effects have been shown to operate. The importance of quantum-chemical calculations in the discovery of noncovalent effects and revealing their significance for the efficiency and selectivity of reductive dehalogenation is also stressed.
- Record ID
- CUT68a10885a866456b9d463737237ce285
- Publication type
- Publication categories
- ; ;
- Author
- Pages
- 302-323
- Other elements of collation
- rys.; Bibliografia (na s.) - 321-323; Bibliografia (liczba pozycji) - 69
- Book
- Mahmudov Kamran T., Kamran T. Mahmudov Kopylovich Maximilian N., Maximilian N. Kopylovich Guedes da Silva M. Fatima C. M. Fatima C. Guedes da Silva [et al.] (eds.): Noncovalent interactions in catalysis, RSC Catalysis Series, no. 36, 2019, London, Royal Society of Chemistry, Royal Society of Chemistry, ISBN 978-1-78801-468-7 (print)
- Keywords in English
- reductive dehalogenation, catalytic dehalogenation, reductive dehalogenases, quantum-chemical calculations, hydrogen bonding, halogen bonding
- DOI
- DOI:10.1039/9781788016490-00302 Opening in a new tab
- URL
- https://pubs.rsc.org/en/Content/Chapter/9781788016490-00302/978-1-78801-649-0 Opening in a new tab
- Language
- eng (en) English
- Score (nominal)
- 20
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT68a10885a866456b9d463737237ce285/
- URN
urn:pkr-prod:CUT68a10885a866456b9d463737237ce285
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