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Solvent-free microwave-assisted synthesis of aripiprazole
Authors:
- Jolanta Jaśkowska,
- Anna K. Drabczyk,
- Damian Kułaga,
- Przemysław Zaręba,
- Zbigniew Majka
Abstract
Aripiprazole is a widely used antipsychotic approved by the FDA (Food and Drug Administration) in 2002. Methods for preparation of aripiprazole mainly involve the use of expensive and toxic solvents, and the reaction time can be even several hours long. Our method allows to obtain aripiprazole with a yield of approximately 70–80% over just a few minutes using solvent-free conditions in the presence of PTC (Phase Transfer Catalysts) and microwave radiation.
- Record ID
- CUT9737e59056c34b35960de69e23836034
- Publication categories
- ;
- Author
- Journal series
- Current Chemistry Letters, ISSN 1927-7296, e-ISSN 1927-730X
- Issue year
- 2018
- Vol
- 7
- No
- 3
- Pages
- 81-86
- Other elements of collation
- rys.; tab.; Bibliografia (na s.) - 85-86; Bibliografia (liczba pozycji) - 23; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 7, Iss. 3
- Keywords in English
- solvent-free synthesis, microwave-assisted synthesis, PTC catalysts, aripiprazole, Long Chain Arylpiperazines (LCAPs)
- DOI
- DOI:10.5267/j.ccl.2018.8.002 Opening in a new tab
- URL
- http://growingscience.com/beta/ccl/2906-solvent-free-microwave-assisted-synthesis-of-aripiprazole.html Opening in a new tab
- Related project
- Synteza i ocena aktywności nowych ligandów działających na receptory ośrodkowego układu nerwowego (oun). . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- License
- Score (nominal)
- 10
- Additional fields
- Indeksowana w: Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT9737e59056c34b35960de69e23836034/
- URN
urn:pkr-prod:CUT9737e59056c34b35960de69e23836034
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.