Fluorescence quenching-based mechanism for determination of hypochlorite by coumarin-derived sensors
Authors:
- Karolina Starzak,
- Arkadiusz Matwijczuk,
- Bernadette Creaven,
- Alicja Matwijczuk,
- Sławomir Wybraniec,
- Dariusz Karcz
Abstract
A fluorescence quenching-based mechanism for the determination of hypochlorite was proposed based on spectroscopic and chromatographic studies on the hypochlorite-sensing potency of three structurally similar and highly fluorescent coumarins. The mode of action was found to rely upon a chlorination of the coumarin-based probes resulting from their reaction with sodium hypochlorite. Importantly, the formation of chlorinated derivatives was accompanied by a linear decrease in the fluorescence intensities of the probes tested. The results obtained suggest the applicability of a coumarin-dependent hypochlorite recognition mechanism for the detection of, as well as for quantitative determination of, hypochlorite species in vitro.
- Record ID
- CUTf06e2e0ea2b941cab0debbee02117e31
- Publication categories
- ;
- Author
- Journal series
- International Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067, Biweekly
- Issue year
- 2019
- Vol
- 20
- No
- 2
- Pages
- [1-15]
- Other elements of collation
- schem.; tab.; wykr.; Bibliografia (na s.) - 13-15; Bibliografia (liczba pozycji) - 52; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 20, Iss. 2
- Keywords in English
- coumarin, hypochlorite sensing, fluorescence quenching
- DOI
- DOI:10.3390/ijms20020281 Opening in a new tab
- URL
- https://www.mdpi.com/1422-0067/20/2/281 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 140
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTf06e2e0ea2b941cab0debbee02117e31/
- URN
urn:pkr-prod:CUTf06e2e0ea2b941cab0debbee02117e31
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.