Spectroscopic studies of dual fluorescence in 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)- 1,3,4-thiadiazole: effect of molecular aggregation in a micellar system
Authors:
- Grzegorz Czernel,
- Arkadiusz Matwijczuk,
- Dariusz Karcz,
- Andrzej Górecki,
- Agnieszka Niemczynowicz,
- Aleksandra Szcześ,
- Grzegorz Gładyszewski,
- Alicja Matwijczuk,
- Bożena Gładyszewska,
- Andrzej Niewiadomy
Abstract
The article presents the results of spectroscopic studies focused on a selected compound from the 1,3,4-thiadiazole group—2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thia-diazole (FABT)—in a micellar system formed by Triton X-100, a non-ionic detergent. Fluorescence measurements revealed the phenomenon of dual fluorescence whose emergence is related to the particular molecular organisation of the compound, which depends both on the concentration of the detergent and, most of all, the concentration of the compound itself. Dual fluorescence of FABT in a micellar system was observed for the compound dissolved in a methanol aqueous system, i.e., an environment wherein the dual fluorescence of the compound had never been reported before. Based on the interpretation of UV-Vis electronic absorption, resonance light scattering (RLS), emission and excitation fluorescence spectra, as well as measurements of dynamic light scattering (DLS) and Principal Component Analysis (PCA), we were able to relate the occurrence of this effect to the process of molecular aggregation taking place between FABT molecules in the micellar system in question. Results of fluorescence spectra measurements and time-correlated single photon counting (TCSPC) indicate that dual fluorescence occurs at detergent concentrations necessary to form micellar systems, which in turn facilitate the process of aggregation of FABT molecules. The correlation between the observed fluorescence effects and the previous measurements performed for analogues from this group suggests the possibility of charge transfer (CT) within the range of detergent concentrations wherein the aforementioned fluorescence effects are observed. It ought to be emphasised that this type of fluorescence effects are relatively easy to induce, which predisposes this groups of fluorophores as ideal fluorescence probes in the context of biological samples.
- Record ID
- CUT86f5b5069b934f44a0579a8a6ad1d288
- Publication categories
- ;
- Author
- Journal series
- Molecules, ISSN , e-ISSN 1420-3049, Biweekly
- Issue year
- 2018
- Vol
- 23
- No
- 11
- Pages
- [1-20]
- Article number
- 2861
- Other elements of collation
- schem.; tab.; wykr.; Bibliografia (na s.) - 18-20; Bibliografia (liczba pozycji) - 45; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 23, Iss. 11
- Keywords in English
- 1,3,4-thiadiazole, molecular spectroscopy, molecular aggregation, induced dual fluorescence effects, micellar systems
- DOI
- DOI:10.3390/molecules23112861 Opening in a new tab
- URL
- https://www.mdpi.com/1420-3049/23/11/2861 Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 30
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT86f5b5069b934f44a0579a8a6ad1d288/
- URN
urn:pkr-prod:CUT86f5b5069b934f44a0579a8a6ad1d288
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