Synthesis and characterization of ceramic – polymer composites containing bioactive synthetic hydroxyapatite for biomedical applications
Authors:
- Agnieszka Sobczak-Kupiec,
- Klaudia Pluta,
- Anna Drabczyk,
- Monika Włoś,
- Bożena Tyliszczak
Abstract
Presented research involved preparation of hydroxyapatite and synthesis of composites based on gelatin, al-bumin and polyvinylpyrrolidone (PVP) modified with the obtained compound. Hydroxyapatite was attained as aproduct of two-stage processing of pig bones. Applied procedure involved hydrolysis of the raw material in acidicenvironment and double calcination. Molar ratio Ca/P of hydroxyapatite has been determined and its chemicalstructure has been characterized using X-ray diffraction and FT-IR spectroscopy. Ratio Ca/P calculated on thebasis of conducted research was 1.50 ± 0.05. Thus prepared material met the ISO requirements, which assumethat the Ca/P ratio should be in the range 1.5–2.0, which qualifies the material for further studies. Next, series ofpolymer matrix on the basis of gelatin, albumin and polyvinylpyrrolidone (PVP) has been synthesized andsubjected to some analyzes. On the basis of the conducted studies, matrixes with the most favorable features suchas desirable strength,flexibility and crosslinking degree were modified with previously prepared hydroxyapatite.Surface morphology and elemental composition of the composites have been analyzed using SEM-EDS method.Additionally, sorption capacity of modified composites and their behavior in simulated bodyfluids have beendetermined. Based on the conducted research it can be concluded that pig bones represent a good material forpreparation of hydroxyapatite. Furthermore, composites based on proteins of natural origin modified with at-tained hydroxyapatite constitute a promising material that can be used for biomedical purposes.
- Record ID
- CUT58ff7248a4e34223aa9cb7317a82cd91
- Publication categories
- ;
- Author
- Journal series
- Ceramics International, ISSN 0272-8842, e-ISSN 1873-3956
- Issue year
- 2018
- Vol
- 44
- No
- 12
- Pages
- 13630-13638
- Other elements of collation
- fot.; tab.; wykr.; Bibliografia (na s.) - 13638; Bibliografia (liczba pozycji) - 27; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 44, Iss. 12
- Keywords in English
- hydroxyapatite, ceramic biomaterials, composites albumin
- DOI
- DOI:10.1016/j.ceramint.2018.04.199 Opening in a new tab
- URL
- https://www.sciencedirect.com/science/article/pii/S0272884218310721 Opening in a new tab
- Related project
- Innowacyjne biomateriały kompozytowe zawierające bioaktywne fosforany wapnia. . Project leader at PK: , ,
Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR (] - Language
- eng (en) English
- Score (nominal)
- 40
- Publication indicators
- = 49
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT58ff7248a4e34223aa9cb7317a82cd91/
- URN
urn:pkr-prod:CUT58ff7248a4e34223aa9cb7317a82cd91
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.