NLCs as a potential carrier system for transdermal delivery of forskolin
Authors:
- Elwira Lasoń,
- Elżbieta Sikora,
- Małgorzata Miastkowska,
- Elvira Escribano,
- Maria Jose Garcia-Celma,
- Conxita Solans,
- Meritxell Llinas,
- Jan Ogonowski
Abstract
Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homog enization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The sys tem’s stability was assessed by macroscopic observa tion, light backscattering and zeta potential measure ments. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concen tration of forskolin in the receptor solution (i.e. ethanol/ PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin.
- Record ID
- CUT5ee799bf997e40cdb435bce8a5a726b7
- Publication categories
- ;
- Author
- Journal series
- Acta Biochimica Polonica, ISSN 0001-527X, e-ISSN 1734-154X
- Issue year
- 2018
- Vol
- 65
- No
- 3
- Pages
- 437-442
- Other elements of collation
- tab.; wykr.; Bibliografia (na s.) - 442; Oznaczenie streszczenia - Streszcz. ang.; Numeracja w czasopiśmie - Vol. 65, No 3
- Keywords in Polish
- forskolin, NLC, nanostructured lipid carrier, skin permeation
- DOI
- DOI:10.18388/abp.2018_2554 Opening in a new tab
- URL
- http://www.actabp.pl/#File?./html/3_2018/2018_2554.html Opening in a new tab
- Related project
- Politechnika XXI wieku – Program rozwojowy Politechniki Krakowskiej – najwyższej jakości dydaktyka dla przyszłych polskich inżynierów. . Project leader at PK: , ,
- Language
- eng (en) English
- License
- Score (nominal)
- 15
- Publication indicators
- = 6
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUT5ee799bf997e40cdb435bce8a5a726b7/
- URN
urn:pkr-prod:CUT5ee799bf997e40cdb435bce8a5a726b7
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.