Chitosan/aminoacid hydrogels with antimicrobial and bioactive properties as new scaffolds for human mesenchymal stem cells culture applicable in wound healing
Authors:
- M. Piątkowski,
- D. Kitala,
- J. Radwan-Pragłowska,
- Ł. Janus,
- A. Klama-Baryła,
- W. Łabuś,
- E. Tomanek,
- J. Glik,
- D. Matýsek,
- M. Kawecki
Abstract
Application of human mesenchymal stem cells brings a new hope for advanced wound healing. To enable cells culture and their viability maintenance, a new type of biomaterials must be developed. Scaffolds prepared from polymers of natural origin can mimic extracellular matrix. Chitosan, which is a chitin derivative, has many favorable properties like biodegradability or lack of cytotoxicity. Therefore, it is widely applied in medicine and pharmacy. Nevertheless, its chemical modification may lead to the loss of biocompatibility of the material and generate some significant problems with cells culture. In this article a novel strategy of the bioactive and antimicrobial chitosan hydrogel scaffolds is presented. As crosslinking agents non-toxic substances were used such as aspartic acid and glutamic acid. Obtained biomaterials were investigated over their chemical structure, morphology and biological activity. Performed tests using human mesenchymal stem cells confirmed bioactivity and biocompatibility, as well as antibacterial and antifungal properties.
- Record ID
- CUTddf1943a627d45589dc0bc9c1d272c87
- Publication categories
- ;
- Author
- Journal series
- Express Polymer Letters, ISSN 1788-618X
- Issue year
- 2018
- Vol
- 12
- No
- 1
- Pages
- 100-112
- Other elements of collation
- fot.; rys.; tab.; wykr.; Bibliografia (na s.) - 111-112; Bibliografia (liczba pozycji) - 21; Oznaczenie streszczenia - Abstr.; Numeracja w czasopiśmie - Vol. 12, No. 1
- Keywords in English
- biocompatible polymers, hydrogel biomaterials, scaffolds, stem cells, chitosan
- DOI
- DOI:10.3144/expresspolymlett.2018.8 Opening in a new tab
- URL
- http://www.expresspolymlett.com/ Opening in a new tab
- Language
- eng (en) English
- License
- Score (nominal)
- 35
- Additional fields
- Indeksowana w: Web of Science, Scopus
- Uniform Resource Identifier
- https://cris.pk.edu.pl/info/article/CUTddf1943a627d45589dc0bc9c1d272c87/
- URN
urn:pkr-prod:CUTddf1943a627d45589dc0bc9c1d272c87
* presented citation count is obtained through Internet information analysis, and it is close to the number calculated by the Publish or PerishOpening in a new tab system.